Department of Biology, University of Tlemcen, 13000, Tlemcen, Algeria.
Analytical Chemistry and Electrochemistry Laboratory, University of Tlemcen, 13000, Tlemcen, Algeria.
J Mol Histol. 2024 Oct;55(5):655-660. doi: 10.1007/s10735-024-10232-2. Epub 2024 Jul 31.
Alpha T-catenin has recently been identified as a crucial tumor suppressor in various cancer types, with roles that go beyond just providing structural support in adherens junctions. This review brings together recent findings on alpha T-catenin's important involvement in key signaling pathways related to cancer progression. We present strong evidence of its regulatory role in Wnt signaling, a pathway often disrupted in colorectal cancer, and explain how it inhibits cell proliferation and tumor growth. We also discuss the significant downregulation of alpha T-catenin in colorectal cancers and its potential as a prognostic marker. Moreover, this review looks at how increasing alpha T-catenin levels can reduce tumor growth and spread, suggesting new therapeutic strategies. Additionally, we reveal alpha T-catenin's unexpected impact on NF-κB signaling in basal E-cadherin-negative breast cancer, expanding its importance across different cancer types. By bringing these findings together, we provide a thorough understanding of alpha T-catenin's tumor-suppressing actions, setting the stage for new targeted therapies and diagnostic tools in cancer treatment.
α-连环蛋白最近被确定为多种癌症类型中的关键肿瘤抑制因子，其作用不仅限于在黏附连接中提供结构支持。这篇综述汇集了最近关于α-连环蛋白在与癌症进展相关的关键信号通路中重要作用的发现。我们提供了强有力的证据表明它在 Wnt 信号通路中的调节作用，该通路在结直肠癌中经常被破坏，并解释了它如何抑制细胞增殖和肿瘤生长。我们还讨论了α-连环蛋白在结直肠癌中的显著下调及其作为预后标志物的潜力。此外，本综述探讨了增加α-连环蛋白水平如何减少肿瘤生长和扩散，提示了新的治疗策略。此外，我们揭示了α-连环蛋白在基底 E-钙黏蛋白阴性乳腺癌中对 NF-κB 信号的意外影响，扩大了其在不同癌症类型中的重要性。通过将这些发现结合在一起，我们对α-连环蛋白的肿瘤抑制作用有了全面的了解，为癌症治疗中的新靶向治疗和诊断工具奠定了基础。
