Key Laboratory of Maternal & Fetal Medicine of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital affiliated to Qingdao University, Jinan, Shandong, China.
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong, China.
Clin Transl Med. 2024 Aug;14(8):e1770. doi: 10.1002/ctm2.1770.
The relationship between noncoding RNAs (ncRNAs) and human diseases has been a hot topic of research, but the study of ncRNAs in cardiovascular diseases (CVDs) is still in its infancy. PIWI-interacting RNA (piRNA), a small ncRNA that binds to the PIWI protein to maintain genome stability by silencing transposons, was widely studied in germ lines and stem cells. In recent years, piRNA has been shown to be involved in key events of multiple CVDs through various epigenetic modifications, revealing the potential value of piRNA as a new biomarker or therapeutic target.
This review explores origin, degradation, function, mechanism and important role of piRNA in CVDs, and the promising therapeutic targets of piRNA were summarized. This review provide a new strategy for the treatment of CVDs and lay a theoretical foundation for future research.
piRNA can be used as a potential therapeutic target and biomaker in CVDs. piRNA influences apoptosis, inflammation and angiogenesis by regulating epigenetic modificaions. Critical knowledge gaps remain in the unifying piRNA nomenclature and PIWI-independent function.
非编码 RNA（ncRNAs）与人类疾病的关系一直是研究的热点，但心血管疾病（CVDs）中 ncRNAs 的研究仍处于起步阶段。PIWI 相互作用 RNA（piRNA）是一种小的 ncRNA，通过沉默转座子与 PIWI 蛋白结合来维持基因组稳定性，在生殖细胞和干细胞中得到了广泛研究。近年来，piRNA 通过多种表观遗传修饰被证明参与多种 CVD 的关键事件，揭示了 piRNA 作为新的生物标志物或治疗靶点的潜在价值。
本综述探讨了 piRNA 在 CVDs 中的起源、降解、功能、机制和重要作用，并总结了 piRNA 的有前途的治疗靶点。本综述为 CVDs 的治疗提供了新的策略，并为未来的研究奠定了理论基础。
piRNA 可以作为 CVDs 潜在的治疗靶点和生物标志物。piRNA 通过调节表观遗传修饰影响细胞凋亡、炎症和血管生成。piRNA 的统一命名法和 PIWI 非依赖性功能方面仍存在关键的知识空白。
