Orthopedics and Traumatology Department of Integrated Traditional Chinese and Western Medicine, Tianjin Hospital, Tianjin, China.
Orthopedics Institute, Tianjin Hospital, Tianjin University, Tianjin, China.
PLoS One. 2024 Jul 31;19(7):e0306792. doi: 10.1371/journal.pone.0306792. eCollection 2024.
Associations between gut microbiota and ankylosing spondylitis have been discovered in previous studies, but whether these associations reflect a causal relationship remains inconclusive. Aiming to reveal the bidirectional causal associations between gut microbiota and ankylosing spondylitis, we utilized publicly available genome wide association study summary data for 211 gut microbiota (GM) taxa and ankylosing spondylitis (AS) to conduct two sample mendelian randomization analyses. Mediation analysis was performed to explore mediating inflammatory cytokines. We found that genetically predicted higher abundance of Lactobacillaceae family, Rikenellaceae family and Howardella genus had suggestive associations with decreased risk of ankylosing spondylitis while genetic proxied higher abundance of Actinobacteria class and Ruminococcaceae_NK4A214_group genus was associated with increased risk of ankylosing spondylitis. IL23 and IFN-γ were potential mediating cytokines for GM dysbiosis, especially for Actinobacteria class, leading to AS. Our study provided a new exploration direction for the treatment of AS. Lactobacillaceae family, Rikenellaceae family, Howardella genus, Actinobacteria class and Ruminococcaceae_NK4A214_group genus are expected to become new therapeutic targets and monitoring indicators for AS.
先前的研究发现了肠道微生物群与强直性脊柱炎之间的关联，但这些关联是否反映了因果关系仍不确定。为了揭示肠道微生物群与强直性脊柱炎之间的双向因果关系，我们利用了已公开的 211 种肠道微生物群（GM）分类群和强直性脊柱炎（AS）的全基因组关联研究汇总数据，进行了两项样本孟德尔随机化分析。中介分析用于探索中介炎症细胞因子。我们发现，遗传预测的乳杆菌科、理研菌科和霍华德菌属丰度较高与强直性脊柱炎风险降低有关，而遗传预测的放线菌纲和真杆菌科_NK4A214_属丰度较高与强直性脊柱炎风险增加有关。IL23 和 IFN-γ 是 GM 失调的潜在中介细胞因子，尤其是对放线菌纲，导致 AS。我们的研究为 AS 的治疗提供了新的探索方向。乳杆菌科、理研菌科、霍华德菌属、放线菌纲和真杆菌科_NK4A214_属有望成为 AS 的新治疗靶点和监测指标。
