School of Public Health, Capital Medical University, Beijing 100069, China.
School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Ecotoxicol Environ Saf. 2024 Sep 15;283:116753. doi: 10.1016/j.ecoenv.2024.116753. Epub 2024 Jul 30.
Limited evidence exists regarding the association between ozone exposure and adverse sperm quality. We aimed to assess the association between ozone exposure and sperm quality, and identify susceptible exposure windows.
We recruited 32,541 men aged between 22 and 65 years old attending an infertility clinic in Wuhan, Hubei Province, China from 2014 to 2020. Ozone data were obtained from a satellite-based spatiotemporal model. Generalized linear models were used to estimate the association between ozone exposure and sperm quality parameters, including sperm concentration, sperm count, sperm total motility, and sperm progressive motility during the entire stage of sperm development (0-90 days before ejaculation) and three crucial stages (0-9 days, 10-14 days and 70-90 days before ejaculation). Stratified analyses were performed to evaluate whether associations varied by age, body mass index, and education levels.
The final analysis included 27,854 adult men. A 10 μg/m increase in ozone concentrations during the entire stage of sperm development was associated with a -4.17 % (95 % CI: -4.78 %, -3.57 %) decrease in sperm concentration, -6.54 % (95 % CI: -8.03 %, -5.60 %) decrease in sperm count, -0.50 % (95 % CI: -0.66 %, -0.34 %) decrease in sperm total motility, and -0.07 % (95 % CI: -0.22 %, 0.09 %) decrease in sperm progressive motility. The associations were stronger during 70-90 days before ejaculation and among men with middle school and lower education for sperm concentration.
Ozone exposure was associated with decreased sperm quality among Chinese adult men attending an infertility clinic. These results suggest that ozone may be a risk factor contributing to decreased sperm quality in Chinese men.
关于臭氧暴露与不良精子质量之间的关联，证据有限。我们旨在评估臭氧暴露与精子质量之间的关联，并确定易感暴露窗口。
我们招募了 2014 年至 2020 年间在中国湖北省武汉市一家不孕不育诊所就诊的年龄在 22 至 65 岁之间的 32541 名男性。臭氧数据来自基于卫星的时空模型。广义线性模型用于估计臭氧暴露与精子质量参数之间的关联，包括精子浓度、精子计数、精子总活力和精子前向运动活力，这些参数在精子发育的整个阶段（射精前 0-90 天）和三个关键阶段（射精前 0-9 天、10-14 天和 70-90 天）进行评估。分层分析用于评估关联是否因年龄、体重指数和教育水平而有所不同。
最终分析包括 27854 名成年男性。在精子发育的整个阶段，臭氧浓度增加 10μg/m 与精子浓度降低 4.17%（95%CI：-4.78%，-3.57%）、精子计数降低 6.54%（95%CI：-8.03%，-5.60%）、精子总活力降低 0.50%（95%CI：-0.66%，-0.34%）和精子前向运动活力降低 0.07%（95%CI：-0.22%，0.09%）相关。这些关联在射精前 70-90 天以及中学及以下教育程度的男性中更为强烈。
臭氧暴露与中国不孕不育诊所就诊的成年男性精子质量下降有关。这些结果表明，臭氧可能是导致中国男性精子质量下降的一个风险因素。
