Garty R, Vaisman H, Tröstler N
Isr J Med Sci. 1985 Oct;21(10):817-21.
The metabolic response to different periods of fasting, ranging from 3 to 7 days, was studied in eight nonobese subjects. Blood ketones rose progressively to 5.07 nmol/l with the prolongation of the fast. The concentrations of glucose and alanine decreased significantly. Valine and leucine rose during fasting but the rise was not statistically significant. Serum triiodothyronine (T3) and insulin decreased, while the urinary excretion of 17-hydroxycorticosteroids (OHCS) doubled. Urea nitrogen decreased in those who fasted 5 to 7 days. Total urinary nitrogen excretion did not change significantly. Excretion of 3-methylhistidine (3-MH) rose during fasting and in some subjects more than doubled when compared with the fed state. The discrepancy between the loss of body protein (calculated by comparing excretion of urinary nitrogen) and the loss of muscle protein (calculated from the excretion of 3-MH) suggests a high rate of recycling of nitrogen during fasting in our subjects.
在8名非肥胖受试者中研究了禁食3至7天不同时间段的代谢反应。随着禁食时间延长，血酮逐渐升高至5.07 nmol/l。葡萄糖和丙氨酸浓度显著降低。缬氨酸和亮氨酸在禁食期间升高，但升高无统计学意义。血清三碘甲状腺原氨酸（T3）和胰岛素降低，而17-羟皮质类固醇（OHCS）的尿排泄量增加一倍。禁食5至7天者尿素氮降低。尿总氮排泄无显著变化。禁食期间3-甲基组氨酸（3-MH）排泄增加，部分受试者与进食状态相比增加超过一倍。根据尿氮排泄计算的身体蛋白质丢失与根据3-MH排泄计算的肌肉蛋白质丢失之间的差异表明，我们的受试者在禁食期间氮的再循环率很高。
