一项关于双相障碍患者尿酸相关生物标志物的大规模研究。

A large-scale study on uric acid-related biomarkers in patients with bipolar disorder.

机构信息

Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, China.

School of Mental Health, Bengbu Medical University, Bengbu, Anhui, China.

出版信息

Psychiatry Res. 2024 Sep;339:116089. doi: 10.1016/j.psychres.2024.116089. Epub 2024 Jul 30.

DOI:10.1016/j.psychres.2024.116089

PMID:39083960

Abstract

OBJECTIVE

Recent research has provided strong evidence supporting the use of uric acid-related ratios as potential biomarkers for disease diagnosis. Notable ratios among these include uric acid-to-albumin ratio (UAR), uric acid-to-creatinine ratio (UCR), uric acid-to-high-density lipoprotein ratio (UHR), and uric acid-to-lymphocyte ratio (ULR). The aim of the study is to analyze these biomarkers in bipolar disorder (BD) patients.

METHODS

5465 BD patients were enrolled in this study and 6629 healthy subjects served as controls. We compared differences of the above ratio indicators among different BD diagnostic groups and analyzed factors leading to the onset of BD.

RESULTS

BD-M (manic episodes of BD) group had higher ULR, UHR, UCR, UAR than HC (Heathy Controls) and BD-D (depressive episodes of BD) groups, while BD-D group showed lower ULR and UCR than HC group. P-BD-M (BD-M with psychotic symptoms) group displayed higher ULR, UHR, UCR, UAR than HC group, while even higher ULR, UHR, UAR than NP-BD-M (BD-M without psychotic symptoms) group. High UAR was risk factor in BD-M.

CONCLUSIONS

Our study suggests BD-M has more intense inflammatory response than BD-D. Furthermore, there is heterogeneity in the pathogenesis of psychotic symptoms between BD-M and BD-D. Additionally, High UAR was risk factor in BD-M.

摘要

目的

最近的研究提供了强有力的证据支持尿酸相关比值作为疾病诊断的潜在生物标志物。这些比值中值得注意的包括尿酸与白蛋白比值（UAR）、尿酸与肌酐比值（UCR）、尿酸与高密度脂蛋白比值（UHR）和尿酸与淋巴细胞比值（ULR）。本研究旨在分析双相障碍（BD）患者的这些生物标志物。

方法

本研究纳入了 5465 例 BD 患者和 6629 例健康对照者。我们比较了不同 BD 诊断组之间上述比值指标的差异，并分析了导致 BD 发病的因素。

结果

BD-M（BD 的躁狂发作）组的 ULR、UHR、UCR、UAR 均高于 HC（健康对照者）和 BD-D（BD 的抑郁发作）组，而 BD-D 组的 ULR 和 UCR 均低于 HC 组。P-BD-M（有精神病症状的 BD-M）组的 ULR、UHR、UCR、UAR 均高于 HC 组，而 ULR、UHR、UAR 均高于 NP-BD-M（无精神病症状的 BD-M）组。高 UAR 是 BD-M 的危险因素。