Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China; De Feng Academy, Southern Medical University, Guangzhou, China.
Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Diabetes Metab Syndr. 2024 Jul;18(7):103091. doi: 10.1016/j.dsx.2024.103091. Epub 2024 Jul 27.
This study aimed to investigate the association between dietary protein intake and mortality among patients with diabetic kidney disease.
The research encompassed a total of 2901 participants diagnosed with diabetic kidney disease, drawn from the National Health and Nutrition Examination Survey (NHANES). To determine outcomes related to all-cause and cardiovascular mortality, connections were established with the National Death Index up until December 31, 2019. Estimations of hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs) were conducted using Cox proportional hazard ratio models.
During the 261,239 person-years of follow-up, 1236 deaths were recorded. After multivariate adjustment, the weighted hazard ratio (HR) and 95 % CIs for participants with 1.0-1.2 g/kg of protein intake was 0.65 (0.44, 0.96) for all-cause mortality. A higher proportion of animal protein intake was found to be associated with an increased mortality risk. Stratified analyses showed that higher protein intake benefited older participants.
In diabetic kidney disease patients, 1.0-1.2 g/kg of protein was associated with lower mortality and 0.6-1.2 g/kg of protein especially benefitted patients ≥60 years.
本研究旨在探讨糖尿病肾病患者的膳食蛋白质摄入量与死亡率之间的关系。
该研究共纳入 2901 名确诊为糖尿病肾病的参与者，他们均来自国家健康和营养调查（NHANES）。为了确定与全因和心血管死亡率相关的结果，研究人员与国家死亡指数建立了联系，直至 2019 年 12 月 31 日。使用 Cox 比例风险比模型对风险比（HR）及其相应的 95%置信区间（CI）进行了估计。
在 261239 人年的随访期间，记录到 1236 例死亡。经过多变量调整后，蛋白质摄入量为 1.0-1.2g/kg 的参与者的全因死亡率的加权风险比（HR）和 95%CI 为 0.65（0.44，0.96）。摄入更多的动物蛋白与更高的死亡风险相关。分层分析表明，较高的蛋白质摄入有益于年龄较大的参与者。
在糖尿病肾病患者中，1.0-1.2g/kg 的蛋白质摄入量与较低的死亡率相关，0.6-1.2g/kg 的蛋白质摄入量尤其有益于≥60 岁的患者。
