术中复合动作电位作为人工耳蜗使用者术后皮层听觉诱发电位的预测指标
Intraoperative Compound Action Potentials as a Predictor of Postoperative Cortical Auditory Evoked Potentials in Cochlear Implant Users.
作者信息
Stutley Alexander, Bogdanov Caris, Voola Marcus Windsor Rao, Friedland Peter, Távora-Vieira Dayse
机构信息
Department of Audiology, Fiona Stanley Fremantle Hospital Group, Perth, Washington, Australia.
Division of Surgery, Medical School, The University of Western Australia, Perth, Washington, Australia.
出版信息
Audiol Neurootol. 2025;30(1):58-69. doi: 10.1159/000540576. Epub 2024 Jul 31.
INTRODUCTION
Electrically evoked cortical auditory evoked potentials (ECAEPs) are central brain responses to auditory stimuli that correlate with postoperative cochlear implant (CI) hearing outcomes. They differ from electrically evoked compound action potentials (ECAPs) which are peripheral responses that can be elicited intraoperatively and may also predict CI hearing outcomes. It is not known to what degree ECAP and ECAEP responses are associated with each other. Such a correlation, if present, may allow for an earlier and more accurate prediction of postoperative hearing outcomes.
METHODS
This retrospective study involved 42 adult CI users. Threshold levels and amplitude growth function slopes of intraoperative ECAPs were compared to the latencies and peak-to-peak amplitudes of postoperative ECAEP responses at three different cochlear electrode array sites (apical, medial, and basal).
RESULTS
A weak positive relationship was found between intraoperative ECAP thresholds and ECAEP N1-P2 peak-to-peak amplitude (r = 0.301, p = 0.005). Time between ECAP and ECAEP measurements was weakly correlated with P1-N1 peak-to-peak amplitude (r = 0.321, p = 0.002) and ECAEP N1-P2 peak-to-peak amplitude (r = 0.340, p = 0.001). ECAP amplitude growth function slopes varied by electrode location (χ2 = 26.701, df = 2, p = 0. 000002).
CONCLUSION
These results suggest that intraoperative ECAP responses do not robustly predict postoperative ECAEP responses, providing caution against the use of ECAPs as a predictive tool for CI hearing outcomes.
INTRODUCTION
Electrically evoked cortical auditory evoked potentials (ECAEPs) are central brain responses to auditory stimuli that correlate with postoperative cochlear implant (CI) hearing outcomes. They differ from electrically evoked compound action potentials (ECAPs) which are peripheral responses that can be elicited intraoperatively and may also predict CI hearing outcomes. It is not known to what degree ECAP and ECAEP responses are associated with each other. Such a correlation, if present, may allow for an earlier and more accurate prediction of postoperative hearing outcomes.
METHODS
This retrospective study involved 42 adult CI users. Threshold levels and amplitude growth function slopes of intraoperative ECAPs were compared to the latencies and peak-to-peak amplitudes of postoperative ECAEP responses at three different cochlear electrode array sites (apical, medial, and basal).
RESULTS
A weak positive relationship was found between intraoperative ECAP thresholds and ECAEP N1-P2 peak-to-peak amplitude (r = 0.301, p = 0.005). Time between ECAP and ECAEP measurements was weakly correlated with P1-N1 peak-to-peak amplitude (r = 0.321, p = 0.002) and ECAEP N1-P2 peak-to-peak amplitude (r = 0.340, p = 0.001). ECAP amplitude growth function slopes varied by electrode location (χ2 = 26.701, df = 2, p = 0. 000002).
CONCLUSION
These results suggest that intraoperative ECAP responses do not robustly predict postoperative ECAEP responses, providing caution against the use of ECAPs as a predictive tool for CI hearing outcomes.
引言
电诱发皮层听觉诱发电位（ECAEPs）是大脑对听觉刺激的中枢反应，与人工耳蜗（CI）术后听力结果相关。它们不同于电诱发复合动作电位（ECAPs），后者是术中可诱发的外周反应，也可能预测CI听力结果。目前尚不清楚ECAP和ECAEP反应之间的关联程度。如果存在这种相关性，可能有助于更早、更准确地预测术后听力结果。
方法
这项回顾性研究纳入了42名成年CI使用者。将术中ECAP的阈值水平和振幅增长函数斜率与术后ECAEP反应在三个不同耳蜗电极阵列部位（顶部、中部和底部）的潜伏期和峰峰值振幅进行比较。
结果
术中ECAP阈值与ECAEP的N1-P2峰峰值振幅之间存在弱正相关（r = 0.301，p = 0.005）。ECAP和ECAEP测量之间的时间与P1-N1峰峰值振幅（r = 0.321，p = 0.002）和ECAEP的N1-P2峰峰值振幅（r = 0.340，p = 0.001）呈弱相关。ECAP振幅增长函数斜率因电极位置而异（χ2 = 26.701，自由度 = 2，p = 0.000002）。
结论
这些结果表明，术中ECAP反应不能可靠地预测术后ECAEP反应，因此在将ECAP用作CI听力结果的预测工具时应谨慎。
引言
电诱发皮层听觉诱发电位（ECAEPs）是大脑对听觉刺激的中枢反应，与人工耳蜗（CI）术后听力结果相关。它们不同于电诱发复合动作电位（ECAPs），后者是术中可诱发的外周反应，也可能预测CI听力结果。目前尚不清楚ECAP和ECAEP反应之间的关联程度。如果存在这种相关性，可能有助于更早、更准确地预测术后听力结果。
方法
这项回顾性研究纳入了42名成年CI使用者。将术中ECAP的阈值水平和振幅增长函数斜率与术后ECAEP反应在三个不同耳蜗电极阵列部位（顶部、中部和底部）的潜伏期和峰峰值振幅进行比较。
结果
术中ECAP阈值与ECAEP的N1-P2峰峰值振幅之间存在弱正相关（r = 0.301，p = 0.005）。ECAP和ECAEP测量之间的时间与P1-N1峰峰值振幅（r = 0.321，p = 0.002）和ECAEP的N1-P2峰峰值振幅（r = 0.340，p = 0.001）呈弱相关。ECAP振幅增长函数斜率因电极位置而异（χ2 = 26.701，自由度 = 2，p = 0.000002）。
结论
这些结果表明，术中ECAP反应不能可靠地预测术后ECAEP反应，因此在将ECAP用作CI听力结果的预测工具时应谨慎。
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