Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.
Toxicol Lett. 2024 Oct;400:49-57. doi: 10.1016/j.toxlet.2024.07.914. Epub 2024 Jul 30.
This study evaluated the effects of long-term polystyrene microplastics (PS-MPs) exposure on hepatic lipid metabolism in vivo by lipidomics.
H&E staining showed long-term PS-MPs exposure could trigger the hepatic inflammatory cell infiltration and hepatic steatosis in SD rats, indicating long-term PS-MPs exposure caused hepatoxicity. Lipidomics revealed that the concentrations of 8 lipid metabolites in the liver were altered after exposure to PS-MPs for both 6 and 12 months, namely LdMePE (16:0), LPC (18:1), LPC (18:2), LPC (20:4), PC (17:0_20:4), PC (18:2_22:6), PC (22:6_13:0) and SM (d18:1_24:0), which were all statistically different from the control groups detected at both time points after PS-MPs exposure, suggesting the mainly metabolic pathway was glycerolipid metabolism.
This study showed chronic exposure to PS-MPs could cause hepatotoxicity and induce hepatic lipidomics alterations in vivo, which could provide an essential clue for the safety assessment of PS-MPs.
本研究通过脂质组学评估长期聚苯乙烯微塑料（PS-MPs）暴露对体内肝脂质代谢的影响。
H&E 染色显示，长期 PS-MPs 暴露可引发 SD 大鼠肝炎性细胞浸润和肝脂肪变性，表明长期 PS-MPs 暴露可导致肝毒性。脂质组学分析显示，暴露于 PS-MPs 6 个月和 12 个月后，肝脏中 8 种脂质代谢物的浓度发生改变，即 LdMePE（16:0）、LPC（18:1）、LPC（18:2）、LPC（20:4）、PC（17:0_20:4）、PC（18:2_22:6）、PC（22:6_13:0）和 SM（d18:1_24:0），与暴露 PS-MPs 后两个时间点的对照组相比，这些代谢物均有统计学差异，表明主要的代谢途径是甘油磷脂代谢。
本研究表明，慢性暴露于 PS-MPs 可导致肝毒性，并在体内诱导肝脂质组学改变，为 PS-MPs 的安全性评估提供了重要线索。
