Division of Nephrology, University of Washington, Seattle, Washington.
Department of Pathology, University of Washington, Seattle, Washington.
Adv Kidney Dis Health. 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008.
Collapsing glomerulopathy (CG) is a pattern of kidney injury characterized by segmental or global collapse of the glomerular tuft associated with overlying epithelial cell hyperplasia. Although CG may be idiopathic, a wide range of etiologies have been identified that can lead to this pattern of injury. Recent advances have highlighted the role of inflammatory and interferon signaling pathways and upregulation of apolipoprotein L1 (APOL1) within podocytes in those carrying a high-risk APOL1 genotype. In this review, we describe the etiology, pathogenesis, pathology, and clinical course of CG, focusing on nonviral etiologies. We also describe current treatments and explore potential therapeutic options targeting interferon/APOL1 pathways in CG.
塌陷性肾小球病 (CG) 是一种肾脏损伤模式，其特征为肾小球簇的节段性或全球性塌陷，伴有上皮细胞过度增生。尽管 CG 可能是特发性的，但已经确定了广泛的病因，这些病因可能导致这种损伤模式。最近的进展强调了炎症和干扰素信号通路的作用，以及携带高风险 APOL1 基因型的足细胞中载脂蛋白 L1 (APOL1) 的上调。在这篇综述中，我们描述了 CG 的病因、发病机制、病理学和临床过程，重点介绍了非病毒病因。我们还描述了目前的治疗方法，并探讨了针对 CG 中干扰素/APOL1 途径的潜在治疗选择。
