催乳素瘤：孕前和孕期。

Prolactinomas: Preconception and During Pregnancy.

机构信息

Department of Medicine, Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, HUB for Collaborative Medicine, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

Department of Medicine, Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, HUB for Collaborative Medicine, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Department of Neurosurgery, Medical College of Wisconsin, HUB for Collaborative Medicine, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

出版信息

Endocrinol Metab Clin North Am. 2024 Sep;53(3):409-419. doi: 10.1016/j.ecl.2024.05.004. Epub 2024 Jun 18.

DOI:10.1016/j.ecl.2024.05.004

PMID:39084816

Abstract

Prolactinomas are a common cause of infertility in women. Medical treatment with dopamine agonists (DAs) has an excellent efficacy at restoring fertility and a reassuring safety profile in early pregnancy. Surgical treatment before conception is required in some cases of large macroadenomas and incomplete treatment response. In women with microprolactinomas, the pregnancy course is usually uneventful. In women with macroprolactinomas that are near/abut the optic chiasm, symptomatic tumor enlargement can occur during pregnancy and require a multidisciplinary team approach. This review provides an update regarding outcomes and management of prolactinomas before conception, during pregnancy, and postpartum.

摘要

催乳素瘤是女性不孕的常见原因。用多巴胺激动剂（DAs）进行医学治疗在恢复生育能力方面效果极好，并且在早孕时具有可靠的安全性。在某些情况下，对于大型大腺瘤和不完全治疗反应，需要在怀孕前进行手术治疗。对于微催乳素瘤患者，妊娠过程通常是顺利的。对于靠近/毗邻视交叉的大催乳素瘤患者，妊娠期间可能会出现有症状的肿瘤增大，需要多学科团队的方法。本文综述了妊娠前、妊娠期间和产后催乳素瘤的结局和管理。