精神分裂症中与髓鞘形成相关基因的失调。
Dysregulation of myelination-related genes in schizophrenia.
机构信息
Department of Molecular and Cell Biology, UC Berkeley, Berkeley, California, USA.
出版信息
J Neurochem. 2024 Sep;168(9):2227-2242. doi: 10.1111/jnc.16152. Epub 2024 Jul 31.
Abstract
Schizophrenic individuals display disrupted myelination patterns, altered oligodendrocyte distribution, and abnormal oligodendrocyte morphology. Schizophrenia is linked with dysregulation of a variety of genes involved in oligodendrocyte function and myelin production. Single-nucleotide polymorphisms (SNPs) and rare mutations in myelination-related genes are observed in certain schizophrenic populations, representing potential genetic risk factors. Downregulation of myelination-related RNAs and proteins, particularly in frontal and limbic regions, is consistently associated with the disorder across multiple studies. These findings support the notion that disruptions in myelination may contribute to the cognitive and behavioral impairments experienced in schizophrenia, although further evidence of causation is needed.
摘要
精神分裂症患者表现出髓鞘形成模式紊乱、少突胶质细胞分布改变和异常的少突胶质细胞形态。精神分裂症与多种参与少突胶质细胞功能和髓鞘生成的基因失调有关。在某些精神分裂症患者群体中观察到与髓鞘形成相关基因的单核苷酸多态性（SNPs）和罕见突变，代表潜在的遗传风险因素。在多个研究中，与该疾病一致相关的是髓鞘形成相关 RNA 和蛋白质的下调，特别是在前额和边缘区域。这些发现支持这样一种观点，即髓鞘形成的破坏可能导致精神分裂症患者的认知和行为障碍，尽管还需要更多因果关系的证据。
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