Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Eur J Neurosci. 2024 Sep;60(5):4982-4986. doi: 10.1111/ejn.16489. Epub 2024 Jul 31.
This opinion piece describes major limitations of using α-synuclein in speculative neuronally enriched for diagnosing or predicting Parkinson's disease risk from prodromal conditions such as REM behaviour disorder. It concludes that such an approach is unreliable and recommends that future researchers divert away to more widely accepted approaches such as seed amplification assays.
这篇观点文章描述了使用α-突触核蛋白来推测神经元富集，以诊断或预测 REM 行为障碍等前驱期条件下帕金森病风险的主要局限性。它得出的结论是，这种方法是不可靠的，并建议未来的研究人员转向更广泛接受的方法，如种子扩增测定。
