Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Division of Preventive Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Gut Liver. 2024 Nov 15;18(6):1080-1084. doi: 10.5009/gnl240063. Epub 2024 Aug 1.
Emerging evidence suggests a broader spectrum of celiac disease (CeD) system involvement, including neurological manifestations. We aimed to conduct a systematic review and meta-analysis of the available evidence from studies assessing the association of cognitive impairment and insomnia with CeD. A total of 259 participants with CeD were included in the studies investigating insomnia and 179 were included in studies investigating cognitive impairment. The overall pooled odds ratio for insomnia in patients with CeD was 1.83 (95% confidence interval, 1.38 to 2.42; I=0.00%). The present study provides valuable insights into the available evidence from studies investigating cognitive impairment in patients with CeD and our systematic review and metaanalysis revealed a significant association between CeD and insomnia.
新出现的证据表明乳糜泻（CeD）系统受累的范围更广，包括神经系统表现。我们旨在对评估认知障碍和失眠与 CeD 相关性的研究进行系统综述和荟萃分析。共有 259 名 CeD 患者的研究纳入失眠评估，179 名患者的研究纳入认知障碍评估。CeD 患者失眠的总体汇总优势比为 1.83（95%置信区间，1.38 至 2.42；I=0.00%）。本研究提供了关于 CeD 患者认知障碍研究的现有证据的有价值的见解，我们的系统综述和荟萃分析显示 CeD 与失眠之间存在显著关联。
