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磷脂酶Cζ：精子在卵母细胞激活和早期胚胎发育中的隐秘作用

Phospholipase C zeta: a hidden face of sperm for oocyte activation and early embryonic development.

作者信息

Azil Soukaina, Mbaye Modou Mamoune, Louanjli Noureddine, Ghazi Bouchra, Benkhalifa Moncef

机构信息

Department of Faculty of Medicine, Mohammed VI University of Health and Sciences, Casablanca, Morocco.

Immunopathology-Immunotherapy-Immunomonitoring Laboratory, Mohammed VI Center for Research & Innovation, Casablanca, Morocco.

出版信息

Obstet Gynecol Sci. 2024 Sep;67(5):467-480. doi: 10.5468/ogs.24019. Epub 2024 Aug 1.

DOI:10.5468/ogs.24019
PMID:39086217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11424188/
Abstract

Oocyte activation is a fundamental event in mammalian fertilization and is initiated by a cascade of calcium signaling and oscillation pathways. Phospholipase C zeta (PLCζ) is involved in modulating cortical granule exocytosis, releasing oocyte meiotic arrest, regulating gene expression, and early embryogenesis. These processes are considered to be initiated and controlled by PLCζ activity via the inositol-1,4,5-triphosphate pathway. The decrease or absence of functional PLCζ due to mutational defects in protein expression or maintenance can impair male fertility. In this literature review, we highlight the significance of PLCζ as a sperm factor involved in oocyte activation, its mechanism of action, the signaling pathway involved, and its close association with oocyte activation. Finally, we discuss the relationship between male infertility and PLCζ deficiency.

摘要

卵母细胞激活是哺乳动物受精过程中的一个基本事件，由一系列钙信号和振荡途径启动。磷脂酶Cζ（PLCζ）参与调节皮质颗粒胞吐作用、解除卵母细胞减数分裂阻滞、调节基因表达以及早期胚胎发育。这些过程被认为是由PLCζ通过肌醇-1,4,5-三磷酸途径的活性启动和控制的。由于蛋白质表达或维持方面的突变缺陷导致功能性PLCζ减少或缺失，会损害男性生育能力。在这篇文献综述中，我们强调了PLCζ作为参与卵母细胞激活的精子因子的重要性、其作用机制、涉及的信号通路以及它与卵母细胞激活的密切关联。最后，我们讨论了男性不育与PLCζ缺乏之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/e019e03c80c0/ogs-24019f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/9881e2a37960/ogs-24019f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/9c19a8c03e58/ogs-24019f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/e019e03c80c0/ogs-24019f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/9881e2a37960/ogs-24019f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/9c19a8c03e58/ogs-24019f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97f4/11424188/e019e03c80c0/ogs-24019f3.jpg

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Obstet Gynecol Sci. 2023 Sep;66(5):430-440. doi: 10.5468/ogs.22170. Epub 2023 Jul 20.
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Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation.ICSI 后完全受精失败：通过人工卵母细胞激活对发病机制、诊断和治疗的深入了解。
Hum Reprod Update. 2023 Jul 5;29(4):369-394. doi: 10.1093/humupd/dmad007.
3
SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency.
精子因素与卵子激活：PLCZ1 与卵母细胞激活缺陷的临床诊断。
Reproduction. 2022 May 23;164(1):F53-F66. doi: 10.1530/REP-21-0458.
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Andrologia. 2022 Feb;54(1):e14269. doi: 10.1111/and.14269. Epub 2021 Oct 15.
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