Bedi Harjot K, Motomura Douglas, Shahidi Neal
Department of Medicine, University of British Columbia, Vancouver V6Z 2K5, BC, Canada.
World J Gastroenterol. 2024 Jul 21;30(27):3278-3283. doi: 10.3748/wjg.v30.i27.3278.
Gastric cancer presents a significant global health burden, as it is the fifth most common malignancy and fourth leading cause of cancer mortality worldwide. Variations in incidence rates across regions underscores the multifactorial etiology of this disease. The overall 5-year survival rate remains low despite advances in its diagnosis and treatment. Although surgical gastrectomy was previously standard-of-care, endoscopic resection techniques, including endoscopic mucosal resection and endoscopic submucosal dissection (ESD) have emerged as effective alternatives for early lesions. Compared to surgical resection, endoscopic resection techniques have comparable 5-year survival rates, reduced treatment-related adverse events, shorter hospital stays and lower costs. ESD also enables resection, thus affording organ-sparing curative endoscopic resection for early cancers. In this editorial, we comment on the recent publication by Geng regarding gastric cystica profunda (GCP). GCP is a rare gastric pseudotumour with the potential for malignant progression. GCP presents a diagnostic challenge due to its nonspecific clinical manifestations and varied endoscopic appearance. There are several gaps in the literature regarding the diagnosis and management of GCP which warrants further research to standardize patient management. Advances in endoscopic resection techniques offer promising avenues for GCP and early gastric cancers.
胃癌是一种重大的全球健康负担，因为它是全球第五大常见恶性肿瘤，也是癌症死亡的第四大主要原因。各地区发病率的差异凸显了该疾病的多因素病因。尽管在诊断和治疗方面取得了进展，但总体5年生存率仍然很低。虽然手术胃切除术以前是标准治疗方法，但包括内镜黏膜切除术和内镜黏膜下剥离术（ESD）在内的内镜切除技术已成为早期病变的有效替代方法。与手术切除相比，内镜切除技术的5年生存率相当，治疗相关不良事件减少，住院时间缩短，成本降低。ESD还能够进行整块切除，从而为早期癌症提供保留器官的根治性内镜切除。在这篇社论中，我们对耿等人最近发表的关于胃深部囊肿（GCP）的文章发表评论。GCP是一种罕见的胃假性肿瘤，具有恶性进展的可能性。由于其非特异性临床表现和多样的内镜表现，GCP提出了诊断挑战。关于GCP的诊断和管理，文献中存在几个空白，需要进一步研究以规范患者管理。内镜切除技术的进展为GCP和早期胃癌提供了有希望的途径。
