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慢性肾脏病患者经导管主动脉瓣置换术后再入院率、预测因素及原因

Rates, predictors, and causes of readmission after transcatheter aortic valve replacement in patients with chronic kidney disease.

作者信息

Teaima Taha, Carlini Gianfranco Bittar, Gajjar Rohan A, Aziz Imran, Shoura Sami J, Shilbayeh Abdul-Rahim, Battikh Naim, Alyousef Tareq

机构信息

Division of Cardiology, Department of Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL 60612, United States.

出版信息

World J Cardiol. 2024 Jul 26;16(7):402-411. doi: 10.4330/wjc.v16.i7.402.

DOI:10.4330/wjc.v16.i7.402
PMID:39086887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11287458/
Abstract

BACKGROUND

Transcatheter aortic valve replacement (TAVR) is a revolutionary procedure for severe aortic stenosis. The coexistence of chronic kidney disease (CKD) and TAVR introduces a challenge that significantly impacts patient outcomes.

AIM

To define readmission rates, predictors, and causes after TAVR procedure in CKD stage 1-4 patients.

METHODS

We used the national readmission database 2018 and 2020 to look into readmission rates, causes and predictors after TAVR procedure in patients with CKD stage 1-4.

RESULTS

Out of 24758 who underwent TAVR and had CKD, 7892 (32.4%) patients were readmitted within 90 days, and had higher adjusted odds of being females (adjusted odds ratio: 1.17, 95%CI: 1.02-1.31, = 0.02) with longer length of hospital stay > 6 days, and more comorbidities including but not limited to diabetes mellitus, anemia, and congestive heart failure (CHF).

CONCLUSION

Most common causes of readmission included CHF (18.0%), sepsis, and complete atrioventricular block. Controlling readmission predictors with very close follow-up is warranted to prevent such high rate of readmission.

摘要

背景

经导管主动脉瓣置换术(TAVR)是治疗严重主动脉瓣狭窄的一项革命性手术。慢性肾脏病(CKD)与TAVR并存带来了一项挑战,对患者预后有显著影响。

目的

确定1-4期CKD患者TAVR术后的再入院率、预测因素及原因。

方法

我们利用2018年和2020年的国家再入院数据库,研究1-4期CKD患者TAVR术后的再入院率、原因及预测因素。

结果

在24758例接受TAVR且患有CKD的患者中,7892例(32.4%)在90天内再次入院,女性再次入院的调整后几率更高(调整优势比:1.17,95%置信区间:1.02-1.31,P = 0.02),住院时间更长>6天,且有更多合并症,包括但不限于糖尿病、贫血和充血性心力衰竭(CHF)。

结论

再入院的最常见原因包括CHF(18.0%)、败血症和完全性房室传导阻滞。有必要通过密切随访控制再入院预测因素,以防止如此高的再入院率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/d4bb6d856600/WJC-16-402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/268fece83751/WJC-16-402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/6d4e47f45d28/WJC-16-402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/d4bb6d856600/WJC-16-402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/268fece83751/WJC-16-402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/6d4e47f45d28/WJC-16-402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/11287458/d4bb6d856600/WJC-16-402-g003.jpg

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Renal Insufficiency Increases the Combined Risk of Left Ventricular Hypertrophy and Dysfunction in Patients at High Risk of Cardiovascular Diseases.肾功能不全增加心血管疾病高危患者左心室肥厚和功能障碍的综合风险。
J Clin Med. 2023 Feb 24;12(5):1818. doi: 10.3390/jcm12051818.
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Low calf circumference adjusted for body mass index is associated with prolonged hospital stay.
小腿围(经体重指数校正)低与住院时间延长有关。
Am J Clin Nutr. 2023 Feb;117(2):402-407. doi: 10.1016/j.ajcnut.2022.11.003. Epub 2022 Dec 15.
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Rehospitalization Events After Aortic Valve Replacement: Insights From the PARTNER Trial.主动脉瓣置换术后再住院事件:PARTNER 试验的观察结果。
Circ Cardiovasc Interv. 2022 Dec;15(12):e012195. doi: 10.1161/CIRCINTERVENTIONS.122.012195. Epub 2022 Dec 20.
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Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction.经导管主动脉瓣置换术与外科主动脉瓣置换术治疗左心功能障碍患者。
J Cardiothorac Surg. 2022 Dec 18;17(1):322. doi: 10.1186/s13019-022-02061-9.
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Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease.终末期肾病患者经导管主动脉瓣置换术后再入院率及再入院风险因素。
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Sex-Based Differences in 30-Day Readmissions After Cardiac Arrest: Analysis of the Nationwide Readmissions Database.基于性别的心脏骤停后 30 天再入院差异:全国再入院数据库分析。
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J Am Heart Assoc. 2022 Aug 16;11(16):e024890. doi: 10.1161/JAHA.121.024890. Epub 2022 Aug 5.
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Evolving Indications of Transcatheter Aortic Valve Replacement-Where Are We Now, and Where Are We Going.经导管主动脉瓣置换术不断演变的适应证——我们现在所处的位置以及未来的方向
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