通过电子给体-受体复合物实现可见光诱导的多米诺全氟烷基化/环化反应以合成全氟烷基化喹唑啉酮
Visible-Light-Induced Domino Perfluoroalkylation/Cyclization to Access Perfluoroalkylated Quinazolinones by an EDA Complex.
作者信息
Meng Fei, Cui Yangyang, Xu Wen, Yang Wen-Chao
机构信息
Institute of Pesticide, College of Plant Protection, Yangzhou University, Yangzhou 225009, China.
出版信息
Org Lett. 2024 Aug 16;26(32):6884-6888. doi: 10.1021/acs.orglett.4c02465. Epub 2024 Aug 1.
The electron donor-acceptor (EDA) complexes have been extensively studied, which formed an electronically excited state, obviating the need for an exogenous photocatalyst. Herein, we report a mild and efficient strategy for photoinduced radical domino perfluoroalkylation/cyclization using ,,','-tetramethylethane-1,2-diamine (TMEDA) as an electron donor. This protocol could be well expanded to access various polycyclic quinazolinones containing perfluoroalkyl groups, exhibiting photocatalyst-free, good functional group tolerance, and environmentally friendly features.
电子供体-受体（EDA）配合物已得到广泛研究，其形成了一个电子激发态，无需外源光催化剂。在此，我们报道了一种温和且高效的策略，使用N,N,N',N'-四甲基乙烷-1,2-二胺（TMEDA）作为电子供体进行光诱导自由基多米诺全氟烷基化/环化反应。该方案可以很好地扩展用于合成各种含全氟烷基的多环喹唑啉酮，具有无催化剂、良好的官能团耐受性和环境友好的特点。
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