Gratsianskiĭ N A, Logutov Iu A, Karpov Iu A, Maevskaia E G, Solov'eva N V
Kardiologiia. 1985 Sep;25(9):91-4.
Effect of 48-72 hour infusion of prostaglandin E1 (PGE1) was studied in 17 patients with angina refractory to conventional medical treatment (combination of propranolol, 160 mg/day nifedipin, 30 mg/day and nitrates) by the double blind test. PGE1 was infused to 11, placebo to 6 patients. There was no difference between PGE1 and placebo groups in the number of ischemic episodes and duration of myocardial ischemia as evidenced by Holter ECG monitoring. But in 2 patients with vasospastic angina attacks of ischemia were almost completely abolished by PGE1.
通过双盲试验，对17例经传统药物治疗（普萘洛尔160毫克/天、硝苯地平30毫克/天和硝酸盐联合使用）仍难治的心绞痛患者进行了前列腺素E1（PGE1）48 - 72小时输注效果的研究。11例患者输注PGE1，6例患者输注安慰剂。动态心电图监测显示，PGE1组和安慰剂组在缺血发作次数和心肌缺血持续时间方面无差异。但在2例血管痉挛性心绞痛患者中，PGE1几乎完全消除了缺血发作。
