Korhonen Liisa, Mogensen Hanna, Erdmann Friederike, Feychting Maria, Frederiksen Line Elmerdahl, Hirvonen Elli, Krøyer Anja, Kyrönlahti Anniina, Malila Nea, Pedersen Camilla, Pitkäniemi Janne, Talbäck Mats, Taskinen Mervi, Winther Jeanette Falck, Madanat-Harjuoja Laura
Finnish Cancer Registry, Helsinki, Finland.
New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Cancer Med. 2024 Aug;13(15):e70067. doi: 10.1002/cam4.70067.
Transitioning to adulthood often involves achieving independence from the parental home. We assessed whether the likelihood of leaving the parental home, cohabitation, and marriage was similar between patients who experienced a hematologic malignancy at a young age and their peers.
We identified 11,575 patients diagnosed with a hematologic malignancy under the age of 20 years between 1971 and 2011 in Denmark, Finland, and Sweden, 57,727 country-, age-, and sex-matched population comparisons and 11,803 sibling comparisons and obtained annual information on family and marital status by linking to the statistical institute databases. Hazard ratios (HR) for leaving the parental home, cohabitation and marriage were estimated using Cox proportional hazards modeling.
Young adults with a history of a hematologic malignancy were slightly less likely to leave the parental home (HR 0.89; 95% confidence interval [CI] 0.86-0.92; HR 0.87 [95% CI 0.82-0.92]), cohabit with a nonmarital partner (HR 0.83 [95%CI 0.78-0.87]; HR 0.84 [95% CI 0.77-0.92]) and be married (HR 0.87 [95% CI 0.82-0.91]; HR 0.86 [95% CI 0.79-0.93]), compared with population comparisons and siblings, respectively.
Our findings provide reassurance that young adults with a history of a hematologic malignancy show only a slight decrease in their likelihood of gaining independence from their childhood family and forming close interpersonal relationships compared to peers. While most patients are coping well in the long term, integrating structured psychosocial support into long-term follow-up is recommended to facilitate a timely and adequate transition into adulthood.
向成年期过渡通常涉及从父母家中独立出来。我们评估了在年轻时经历血液系统恶性肿瘤的患者与同龄人离开父母家、同居和结婚的可能性是否相似。
我们在丹麦、芬兰和瑞典确定了1971年至2011年期间11575例20岁以下被诊断患有血液系统恶性肿瘤的患者、57727例按国家、年龄和性别匹配的人群对照以及11803例同胞对照，并通过与统计机构数据库链接获取有关家庭和婚姻状况的年度信息。使用Cox比例风险模型估计离开父母家、同居和结婚的风险比（HR）。
与人群对照和同胞相比，有血液系统恶性肿瘤病史的年轻人离开父母家的可能性略低（HR 0.89；95%置信区间[CI] 0.86 - 0.92；HR 0.87 [95% CI 0.82 - 0.92]），与非婚姻伴侣同居的可能性略低（HR 0.83 [95%CI 0.78 - 0.87]；HR 0.84 [95% CI 0.77 - 0.92]），结婚的可能性略低（HR 0.87 [95% CI 0.82 - 0.91]；HR 0.86 [95% CI 0.79 - 0.93]）。
我们的研究结果让人放心，有血液系统恶性肿瘤病史的年轻人与同龄人相比，从童年家庭中独立出来并建立亲密人际关系的可能性仅略有下降。虽然大多数患者长期应对良好，但建议将结构化的心理社会支持纳入长期随访，以促进及时、充分地过渡到成年期。
