Social Pharmacy Department, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Department of Research and Development, Ezequiel Dias Foundantion, Belo Horizonte, Brazil.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2024;59(6):305-320. doi: 10.1080/10934529.2024.2384216. Epub 2024 Aug 1.
is a brine shrimp genus adapted to extreme habitats like ranges salinity from 5-25 g/L and in temperatures from 9 to 35 °C. It is widely distributed and used as an environmental quality biomarker. and species are commonly used in ecotoxicological studies and genotoxicity assays due to their short life cycle, high fecundity rate, easy culture, and availability. Thus, considering the importance of these tests in ecotoxicological studies, the present study aimed to present genus as a biological model in genotoxicity research. To this end, we reviewed the literature, analyzing data published until July 2023 in the Web of Science, SCOPUS, Embase, and PubMed databases. After screening, we selected 34 studies in which the genotoxicity of for various substances. This review presents the variability of the experimental planning of assays and biomarkers in genotoxicity using genus as a biological model for ecotoxicological studies and show the possibility of monitoring biochemical alterations and genetic damage effects. Also highlight innovative technologies such as transcriptomic and metabolomic analysis, as well as studies over successive generations to identify changes in DNA and consequently in gene expression.
是一种适应极端生境的卤虫属，其盐度范围为 5-25g/L，温度范围为 9-35°C。它分布广泛，可用作环境质量生物标志物。和 物种由于其生命周期短、高繁殖率、易于培养和可用性而常用于生态毒理学研究和遗传毒性测定。因此，考虑到这些测试在生态毒理学研究中的重要性，本研究旨在将 属作为遗传毒性研究中的生物模型进行介绍。为此，我们综述了文献，分析了截至 2023 年 7 月在 Web of Science、SCOPUS、Embase 和 PubMed 数据库中发表的数据。经过筛选，我们选择了 34 项研究，其中涉及各种物质对 属的遗传毒性。本综述展示了使用 属作为生态毒理学研究的生物模型进行遗传毒性测定时实验规划和生物标志物的可变性，并显示了监测生化改变和遗传损伤效应的可能性。还强调了转录组学和代谢组学分析等创新技术，以及用于识别 DNA 和随后基因表达变化的连续几代研究。
