邻苯二甲酸二（2-乙基己基）酯（DEHP）对秀丽隐杆线虫生存和繁殖力影响的评估。
Evaluation of the Effects of Di-(2-ethylhexyl) phthalate (DEHP) on Caenorhabditis elegans Survival and Fertility.
作者信息
Zöngür Alper
机构信息
Gemerek Vocational School, Sivas Cumhuriyet University, Sivas, Turkey.
出版信息
Appl Biochem Biotechnol. 2024 Dec;196(12):8998-9009. doi: 10.1007/s12010-024-05032-z. Epub 2024 Aug 1.
Di-2-ethylhexyl (DEHP), which is widely used in industrial products, is produced annually in excess of 2 million tons worldwide. DEHP is an endocrine disruptor and one of the major environmental pollutant chemicals (EDCs) in nature. There is some information about the effects of these products, which provide great advantages in every respect, on human health and the environment. In this study, C. elegans organism was used to evaluate the health and environmental risks of DEHP. The survival and fertility effects of DEHP on the C. elegans organism were examined and the results were evaluated. In the study, it was determined that DEHP not only shortened the survival time of C. elegans but also caused a decrease in fertility. DEHP (0.625 mM and 10 mM) caused a 23.2-30.6% decrease in fertility. Additionally, the LC (50% lethal concentration) value of DEHP was found to be 321 µg/mL.
二（2-乙基己基）邻苯二甲酸酯（DEHP）广泛应用于工业产品中，全球年产量超过200万吨。DEHP是一种内分泌干扰物，也是自然界中主要的环境污染物化学物质（EDCs）之一。关于这些在各方面都具有巨大优势的产品对人类健康和环境的影响，有一些相关信息。在本研究中，利用秀丽隐杆线虫来评估DEHP对健康和环境的风险。检测了DEHP对秀丽隐杆线虫的生存和繁殖影响，并对结果进行了评估。研究发现，DEHP不仅缩短了秀丽隐杆线虫的存活时间，还导致繁殖力下降。DEHP（0.625 mM和10 mM）使繁殖力下降了23.2 - 30.6%。此外，发现DEHP的LC（50%致死浓度）值为321 μg/mL。
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