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新生儿先天性牙龈瘤;病例报告。

Congenital epulis of the newborn; A case report.

作者信息

Abera Kirubel Addisu, Yefter Ermias Teklehaimanot, Alemayehu Kalkidan Asaye, Zegeye Kassa Berie, Tadesse Amanuel Kassa, Workneh Zelallem Aniley

机构信息

Department of Anatomic Pathology, College of Medicine and Health Sciences, University of Gondar, Maraki 196, Gondar, Ethiopia.

Department of Anatomic Pathology, College of Medicine and Health Sciences, University of Gondar, Maraki 196, Gondar, Ethiopia.

出版信息

Int J Surg Case Rep. 2024 Sep;122:110085. doi: 10.1016/j.ijscr.2024.110085. Epub 2024 Jul 27.

Abstract

INTRODUCTION

Congenital epulis, also known as Neumann's tumor, is an uncommon benign tumor of the oral mucosa that occurs in newborns. It is a rare condition, with fewer than 250 reported cases worldwide. The exact cause or underlying mechanism of this tumor is still not well understood.

CASE PRESENTATION

We present a three-day-old male neonate who presented with a swelling on the gingiva that had been present since birth. The infant did not encounter any difficulties with feeding or breathing. The patient had a single, round, pink swelling measuring 2 × 2 × 1 cm on the right maxillary alveolar ridge. The swelling was surgically removed under general anesthesia. Microscopic examination revealed large polygonal cells with abundant granular cytoplasm, centrally located nuclei indicating a diagnosis of congenital epulis.

CLINICAL DISCUSSION

Clinical manifestation could vary from no symptoms to feeding difficulty and rarely airway obstruction. It usually tends to grow on anterior alveolar ridge of the newborns, more on the maxilla than on the mandible. Confirmation of the diagnosis is by histopathology, which commonly shows proliferation of polygonal round cells with eosinophilic granular cytoplasm and round central nucleus. Congenital epulis can be approached using different management techniques depending on the size, site of the tumor, and presenting symptoms of the newborns.

CONCLUSION

Congenital epulis is rare, but it has to be considered as a differential diagnosis for gingival swelling among neonates.

摘要

引言

先天性牙龈瘤,也称为诺伊曼肿瘤,是一种发生于新生儿口腔黏膜的罕见良性肿瘤。它是一种罕见疾病,全球报道病例少于250例。该肿瘤的确切病因或潜在机制仍未完全明确。

病例介绍

我们报告一名3日龄男性新生儿,自出生以来牙龈处就有肿胀。该婴儿在喂养或呼吸方面未遇到任何困难。患者右侧上颌牙槽嵴有一个单一的圆形粉红色肿物,大小为2×2×1厘米。在全身麻醉下将肿物手术切除。显微镜检查显示有大的多边形细胞,细胞质丰富且呈颗粒状,细胞核位于中央,诊断为先天性牙龈瘤。

临床讨论

临床表现可从无症状到喂养困难,很少出现气道梗阻。它通常倾向于生长在新生儿的前牙槽嵴,在上颌比在下颌更常见。通过组织病理学确诊,其通常显示多边形圆形细胞增殖,细胞质呈嗜酸性颗粒状,细胞核圆形。根据肿瘤大小、部位以及新生儿的症状,可采用不同的治疗技术处理先天性牙龈瘤。

结论

先天性牙龈瘤很罕见,但在新生儿牙龈肿胀的鉴别诊断中必须考虑到它。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29cd/11342214/64d55bbd6f26/gr1.jpg

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