State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China; Key Laboratory of Food Quality and Health of Tianjin, Tianjin University of Science and Technology, Tianjin 300457, China.
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China; Key Laboratory of Food Quality and Health of Tianjin, Tianjin University of Science and Technology, Tianjin 300457, China.
Food Chem. 2024 Dec 1;460(Pt 2):140660. doi: 10.1016/j.foodchem.2024.140660. Epub 2024 Jul 27.
This study utilized computational simulation and surface molecular imprinting technology to develop a magnetic metal-organic framework molecularly imprinted polymer (FeO@ZIF-8@SMIP) capable of selectively recognizing and detecting multiple fluoroquinolones (FQs). The FeO@ZIF-8@SMIP material was synthesized using the "common" template-ofloxacin, identified by computational simulation, demonstrating notable adsorption capacity (88.61-212.93 mg g) and rapid mass-transfer features (equilibration time: 2-3 min) for all tested FQs, consistent with Langmuir adsorption model. Subsequently, this material was employed as a magnetic solid-phase-extraction adsorbent for adsorption and detection of multiple FQs by combining with high performance liquid chromatography. The developed method exhibited good linearity for various FQs within the concentration range of 0.1-500 μg L, with low limit of detection (0.0605-0.1529 μg L) and limit of quantitation (0.2017-0.5097 μg L). Satisfactory recoveries (88.38-103.44%) were obtained when applied to spiked food samples, demonstrating the substantial potential of this FeO@ZIF-8@SMIP material for rapid enrichment and identification for multiple FQs residues.
本研究利用计算模拟和表面分子印迹技术，开发了一种可选择性识别和检测多种氟喹诺酮类药物（FQs）的磁性金属有机骨架分子印迹聚合物（FeO@ZIF-8@SMIP）。该 FeO@ZIF-8@SMIP 材料是使用计算模拟确定的“通用”模板氧氟沙星合成的，表现出显著的吸附能力（88.61-212.93mg/g）和快速的传质特性（平衡时间：2-3min），适用于所有测试的 FQs，符合朗缪尔吸附模型。随后，该材料通过与高效液相色谱相结合，作为一种磁性固相萃取吸附剂，用于多种 FQs 的吸附和检测。所开发的方法在 0.1-500μg/L 的浓度范围内对各种 FQs 表现出良好的线性，检测限低（0.0605-0.1529μg/L），定量限低（0.2017-0.5097μg/L）。当应用于加标食品样品时，获得了令人满意的回收率（88.38-103.44%），表明这种 FeO@ZIF-8@SMIP 材料具有快速富集和识别多种 FQs 残留的巨大潜力。
