维持性血液透析患者血清 Klotho、胎球蛋白-A 和基质 Gla 蛋白水平与冠状动脉钙化的相关性。
Correlation of serum Klotho, fetuin-A, and MGP levels with coronary artery calcification in maintenance hemodialysis patients.
机构信息
Department of East Hospital Nephrology, Yantaishan Hospital, Yantai City, Shandong Province, China.
Department of Nephrology, The People's Hospital of Xushui, Baoding City, Hebei Province, China.
出版信息
Clinics (Sao Paulo). 2024 Jul 31;79:100417. doi: 10.1016/j.clinsp.2024.100417. eCollection 2024.
OBJECTIVE
This study was to investigate the role of serum Klotho, fetuin-A, and Matrix Gla Protein (MGP) in Coronary Artery Calcification (CAC) in patients with Maintenance Hemodialysis (MHD) and their predictive value for CAC.
METHODS
100 patients receiving MHD were selected. Serum Klotho, fetuin-A, and MGP levels were detected by ELISA. CAC scores were assessed by coronary CT scan. Multifactor analysis was used to evaluate the risk factors affecting CAC. The ability of serum Klotho, fetuin-A, and MGP levels to diagnose CAC was evaluated by receiver operating characteristic curves.
RESULTS
Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC. Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.
CONCLUSION
There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.
目的
本研究旨在探讨维持性血液透析（MHD）患者血清 Klotho、胎球蛋白-A 和基质 Gla 蛋白（MGP）在冠状动脉钙化（CAC）中的作用及其对 CAC 的预测价值。
方法
选取 100 例接受 MHD 的患者。采用 ELISA 法检测血清 Klotho、胎球蛋白-A 和 MGP 水平。通过冠状动脉 CT 扫描评估 CAC 评分。采用多因素分析评估影响 CAC 的危险因素。通过受试者工作特征曲线评估血清 Klotho、胎球蛋白-A 和 MGP 水平诊断 CAC 的能力。
结果
血清 Klotho、胎球蛋白-A 和 MGP 是 CAC 的独立危险因素。血清 Klotho、胎球蛋白-A 和 MGP 对 MHD 患者 CAC 的诊断具有重要价值。
结论
MHD 患者 Klotho、胎球蛋白-A 和 MGP 水平与 CAC 密切相关。
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