Department of Forensic Toxicological Analysis, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
West China School of Public Health and West China Fourth Hospital, Chengdu, 610016, Sichuan, China.
J Forensic Leg Med. 2024 Aug;106:102732. doi: 10.1016/j.jflm.2024.102732. Epub 2024 Jul 30.
Glufosinate is a widely and increasingly used non-selective, broad-spectrum herbicide. Although cases of glufosinate poisoning are frequently reported, they are rarely documented in forensic case reports, particularly in fatal instances. The present study examined six cases of glufosinate poisoning, including a fatal case involving a 25-year-old female found deceased by the roadside, with an empty 1000 mL bottle labeled "glufosinate" by her side. Biological specimens such as plasma or cardiac blood, gastric contents, and liver tissues were collected for quantitative analysis of glufosinate levels using LC-MS/MS. In five cases of acute glufosinate poisoning, glufosinate plasma concentrations ranged from 0.62 to 3.92 μg/mL. In the fatal case, the concentrations of glufosinate in cardiac blood, gastric contents, and liver tissues were 8.41 μg/mL, 31.25 μg/mL, and 66.1 μg/g, respectively. The pathological autopsy concluded that the cause of death was acute cardio-respiratory failure due to glufosinate poisoning, characterized by multi-organ congestion without specific pathological findings. The toxicological data provided in this study aim to serve as a critical reference for future clinical treatment and forensic validation of glufosinate poisoning-related deaths.
草铵膦是一种广泛且日益使用的非选择性、广谱除草剂。尽管草铵膦中毒的病例经常被报道，但在法医案例报告中却很少被记录，特别是在致命的情况下。本研究检查了 6 例草铵膦中毒病例，包括一例 25 岁女性的致命病例，她被发现死在路边，身边有一个空的 1000 毫升装的“草铵膦”标签瓶。采集了血浆或心血、胃内容物和肝组织等生物标本，使用 LC-MS/MS 进行草铵膦水平的定量分析。在 5 例急性草铵膦中毒病例中，草铵膦的血浆浓度范围为 0.62 至 3.92μg/mL。在致命病例中，心血、胃内容物和肝组织中的草铵膦浓度分别为 8.41μg/mL、31.25μg/mL 和 66.1μg/g。病理尸检结论为草铵膦中毒导致的急性心肺衰竭死亡，其特征为多器官充血，无特定的病理发现。本研究提供的毒理学数据旨在为未来的临床治疗和法医验证草铵膦中毒相关死亡提供关键参考。
