Dahl A R
Mutat Res. 1985 Dec;158(3):141-7. doi: 10.1016/0165-1218(85)90077-1.
6 nitrosamines, 5 of which cause rat nasal cancer, were tested for mutagenicity in the TA100 strain of S. typhimurium with rat and rabbit nasal, lung and liver S9 homogenates. The TA98 strain also was used with rabbit tissue homogenates. The two cyclic nitrosamines tested, N-nitrosopiperidine and N-nitrosopyrrolidine, were substantially mutagenic with all rabbit tissue homogenates in TA100, but in the rat only nasal homogenate was effective in activating them. N-Nitrosodi(n)propylamine also was activated by rat nasal tissue homogenate but not by the other rat or rabbit tissue homogenates. Diethanolnitrosamine was a direct mutagen in both TA100 and TA98. N-Nitrosodimethylamine and N-nitrosodiethylamine were not mutagenic under any test conditions. The results indicate that some nitrosamines that cause nasal cancer can be activated by nasal enzymes and that possibly important differences in activating capabilities occur among respiratory tract and hepatic tissues and among animal species.
对6种亚硝胺进行了测试，其中5种会导致大鼠鼻癌，利用大鼠和兔子的鼻、肺及肝脏S9匀浆，在鼠伤寒沙门氏菌TA100菌株中检测它们的致突变性。TA98菌株也与兔子组织匀浆一起使用。所测试的两种环状亚硝胺，N-亚硝基哌啶和N-亚硝基吡咯烷，在TA100中与所有兔子组织匀浆一起时具有显著的致突变性，但在大鼠中只有鼻匀浆能有效激活它们。N-亚硝基二丙胺也能被大鼠鼻组织匀浆激活，但不能被其他大鼠或兔子组织匀浆激活。二乙醇亚硝胺在TA100和TA98中都是直接诱变剂。N-亚硝基二甲胺和N-亚硝基二乙胺在任何测试条件下都没有致突变性。结果表明，一些导致鼻癌的亚硝胺可被鼻酶激活，并且在呼吸道和肝脏组织以及动物物种之间，激活能力可能存在重要差异。
