Key Laboratory of Precision Nutrition and Health, Ministry of Education, Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, PR China; Department of Toxicology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province 150081, PR China.
Center for Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.
Sci Total Environ. 2024 Nov 15;951:175150. doi: 10.1016/j.scitotenv.2024.175150. Epub 2024 Jul 30.
Maternal smoking during pregnancy (MSDP) is significantly linked to the short- or long-term health of offspring. However, little research has examined whether MSDP affect the aging rate of offspring.
This study used questionnaires to determine out whether the participants' mothers smoked when they were pregnant. For evaluating aging rate, we used the following several outcome measures: telomere length, frailty index, cognitive function, homeostatic dysregulation score, KDM-age, age-related hospitalization rate, premature death, and life expectancy.
After adjusting for covariates, we found that the offspring of the MSDP group had significantly shorter telomere length in adulthood by 0.8 % (β = -0.008,95%CI:-0.009 to -0.006) compared with non-MSDP group. Compared to the non-MSDP group, participants in MSDP group showed higher levels of homeostatic dysregulation (β = 0.015,95%CI: 0.007-0.024) and were frailer (β = 0.008,95%CI:0.007-0.009). The KDM age increased by 0.100 due to MSDP (β = 0.100,95 % CI:0.018-0.181), and the age acceleration of KDM algorithm also increases significantly (β = 0.101, 95%CI:0.020-0.183). Additionally, we found that the risk of aging-related hospitalizations was significantly higher than the non-MSDP group by 10.4 %(HR = 1.104,95%CI:1.066-1.144). Moreover, MSDP group had a 12.2 % increased risk of all-cause premature mortality (HR = 1.122,95%CI:1.064-1.182) and a significant risk of lung cancer-specific premature mortality increased by 55.4 %(HR = 1.554,95%CI:1.346-1.793). In addition, participants in the MSDP group had significantly decreased cognitive function and shorter life expectancies than those in non-MSDP group.
Our findings indicated a significant association between MSPD and accelerated aging, elevated hospitalization rates, increased premature mortality rates, and reduced life expectancies in offspring.
母亲在怀孕期间吸烟（MSDP）与后代的短期或长期健康显著相关。然而，很少有研究探讨 MSDP 是否会影响后代的衰老速度。
本研究使用问卷来确定参与者的母亲在怀孕期间是否吸烟。为了评估衰老速度，我们使用了以下几种结果测量指标：端粒长度、虚弱指数、认知功能、内稳态失调评分、KDM-age、与年龄相关的住院率、过早死亡和预期寿命。
在调整了协变量后，我们发现 MSDP 组的后代在成年后端粒长度明显缩短了 0.8%（β=-0.008，95%CI：-0.009 至-0.006），与非 MSDP 组相比。与非 MSDP 组相比，MSDP 组的参与者表现出更高的内稳态失调水平（β=0.015，95%CI：0.007-0.024），并且更虚弱（β=0.008，95%CI：0.007-0.009）。由于 MSDP，KDM 年龄增加了 0.100（β=0.100，95%CI：0.018-0.181），并且 KDM 算法的年龄加速也显著增加（β=0.101，95%CI：0.020-0.183）。此外，我们发现与衰老相关的住院风险比非 MSDP 组高 10.4%（HR=1.104，95%CI：1.066-1.144）。此外，MSDP 组全因过早死亡的风险增加了 12.2%（HR=1.122，95%CI：1.064-1.182），肺癌特异性过早死亡的风险显著增加了 55.4%（HR=1.554，95%CI：1.346-1.793）。此外，MSDP 组的参与者认知功能明显下降，预期寿命短于非 MSDP 组。
我们的研究结果表明，MSDP 与后代的加速衰老、住院率升高、过早死亡率升高以及预期寿命缩短之间存在显著关联。
