Department of Pediatrics, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision Nutrition and Health, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, China.
Arch Gerontol Geriatr. 2024 Dec;127:105600. doi: 10.1016/j.archger.2024.105600. Epub 2024 Aug 12.
Exploring the association between Childhood Emotional Support (CES) and the mechanisms of aging is pivotal for understanding its potential to lessen the incidence of age-related pathologies and promote a milieu for healthy aging.
Utilizing data from the UK Biobank comprising nearly 160,000 individuals, comprehensive analyses were conducted to explore associations between CES levels and age-related diseases, biological age and aging hallmarks. Cox proportional hazards regression models were used to investigate the relationship between CES and the risk of hospitalization for age-related diseases. Linear regression models were employed to explore the associations between CES and the frailty index (FI), Klemera-Doubal method (KDM) biological age acceleration, homeostatic dysregulation (HD), C-reactive protein (CRP), white blood cell (WBC) count, and telomere length.
The analyses revealed a significant association between higher CES levels and a decreased risk of hospitalization for age-related diseases in later life. After adjustments for covariates, the hazard ratio for age-related diseases was 0.87 (95 % confidence interval, 0.83-0.91, p < 0.001) in those with the highest CES level compared to those with the lowest CES level. Participants with the highest CES level exhibited lower FI scores (coefficient = -0.033, p < 0.001), reduced CRP level (coefficient = -0.097, p < 0.05) and lower WBC counts (coefficient = -0.034, p < 0.05). Stratified analyses based on genetic susceptibility further elucidated the protective role of CES against age-related diseases.
These findings underscore the potential of early interventions targeting CES to promote healthy aging and alleviating the burden of age-related diseases.
探索儿童情感支持（CES）与衰老机制之间的关联对于理解其减轻与年龄相关的病理发病率和促进健康衰老环境的潜力至关重要。
利用来自英国生物库的近 16 万人的数据，进行了综合分析，以探讨 CES 水平与与年龄相关的疾病、生物年龄和衰老标志之间的关联。使用 Cox 比例风险回归模型研究 CES 与与年龄相关的疾病住院风险之间的关系。线性回归模型用于研究 CES 与虚弱指数（FI）、Klemera-Doubal 方法（KDM）生物年龄加速、体内平衡失调（HD）、C-反应蛋白（CRP）、白细胞（WBC）计数和端粒长度之间的关联。
分析表明，CES 水平较高与晚年与年龄相关的疾病住院风险降低显著相关。在调整了协变量后，与 CES 水平最低的参与者相比，CES 水平最高的参与者患与年龄相关的疾病的风险比为 0.87（95%置信区间，0.83-0.91，p<0.001）。CES 水平最高的参与者的 FI 评分较低（系数=-0.033，p<0.001）、CRP 水平降低（系数=-0.097，p<0.05）和 WBC 计数较低（系数=-0.034，p<0.05）。基于遗传易感性的分层分析进一步阐明了 CES 对与年龄相关的疾病的保护作用。
这些发现强调了早期针对 CES 的干预措施在促进健康衰老和减轻与年龄相关的疾病负担方面的潜力。
