ATP 驱动的外排体 ATAD1/Msp1 校对蛋白质向线粒体的易位。
The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria.
机构信息
Institute of Cell Dynamics and Imaging, University of Münster, Münster, Germany; Cells in Motion Interfaculty Centre (CiM), University of Münster, Münster, Germany.
Cells in Motion Interfaculty Centre (CiM), University of Münster, Münster, Germany; Institute of Medical Physics and Biophysics and Center for Soft Nanoscience, University of Münster, Münster, Germany.
出版信息
Trends Cell Biol. 2024 Sep;34(9):698-699. doi: 10.1016/j.tcb.2024.07.007. Epub 2024 Aug 1.
The accumulation of translocation intermediates in the mitochondrial import machinery threatens cellular fitness and is associated with cancer and neurodegeneration. A recent study by Weidberg and colleagues identifies ATAD1 as an ATP-driven extraction machine on the mitochondrial surface that pulls precursors into the cytosol to prevent clogging of mitochondrial import pores.
易位中间产物在线粒体输入机制中的积累威胁着细胞的适应性，与癌症和神经退行性疾病有关。Weidberg 及其同事的一项最新研究确定 ATAD1 是线粒体表面的一种 ATP 驱动的提取机器，它将前体拉入细胞质，以防止线粒体输入孔堵塞。
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