Department of Infection Control Science, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Department of Infectious Disease Medicine, Osaka Metropolitan University Hospital, Osaka, Japan.
Mycoses. 2024 Aug;67(8):e13773. doi: 10.1111/myc.13773.
Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is one of the noticeable complications of COVID-19 and its incidence varies widely. In Japan, research on the incidence, risk factors and mortality associated with CAPA is limited.
This study aimed to explore the incidence and potential risk factors for CAPA in patients with severe or critical COVID-19 and evaluate the relationship between CAPA and mortality of patients with severe or critical COVID-19.
We investigated the incidence of CAPA in patients with severe and critical COVID-19 using administrative claims data from acute care hospitals in Japan. We employed multivariable regression models to explore potential risk factors for CAPA and their contribution to mortality in patients with severe and critical COVID-19.
The incidence of CAPA was 0.4%-2.7% in 33,136 patients with severe to critical COVID-19. Age, male sex, chronic lung disease, steroids, immunosuppressants, intensive care unit admission, blood transfusion and dialysis were potential risk factors for CAPA in patients with severe to critical COVID-19. CAPA was an independent factor associated with mortality.
CAPA is a serious complication in patients with severe and critical COVID-19 and may increase mortality.
2019 年冠状病毒病（COVID-19）相关肺曲霉病（CAPA）是 COVID-19 的显著并发症之一，其发病率差异很大。在日本，关于 CAPA 的发病率、危险因素和死亡率的研究有限。
本研究旨在探讨重症或危重症 COVID-19 患者中 CAPA 的发病率和潜在危险因素，并评估 CAPA 与重症或危重症 COVID-19 患者死亡率之间的关系。
我们使用日本急性护理医院的行政索赔数据调查了重症和危重症 COVID-19 患者中 CAPA 的发病率。我们采用多变量回归模型探讨了 CAPA 的潜在危险因素及其对重症和危重症 COVID-19 患者死亡率的影响。
在 33136 例重症至危重症 COVID-19 患者中，CAPA 的发病率为 0.4%-2.7%。年龄、男性、慢性肺部疾病、类固醇、免疫抑制剂、重症监护病房入院、输血和透析是重症至危重症 COVID-19 患者中 CAPA 的潜在危险因素。CAPA 是与死亡率相关的独立因素。
CAPA 是重症和危重症 COVID-19 患者的严重并发症，可能会增加死亡率。
