Xu Ting-Ting, Deng Ying-Yi, Yu Xi-Yong, Li Min, Fu Yuan-Yuan
NMPA Key Laboratory for Clinical Research and Evaluation of Drug for Thoracic Diseases, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.
School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Acta Pharmacol Sin. 2025 Jan;46(1):8-32. doi: 10.1038/s41401-024-01356-y. Epub 2024 Aug 1.
Non-communicable diseases (NCDs) are defined as a kind of diseases closely related to bad behaviors and lifestyles, e.g., cardiovascular diseases, cancer, and diabetes. Driven by population growth and aging, NCDs have become the biggest disease burden in the world, and it is urgent to prevent and control these chronic diseases. Autophagy is an evolutionarily conserved process that degrade cellular senescent or malfunctioning organelles in lysosomes. Mounting evidence has demonstrated a major role of autophagy in the pathogenesis of cardiovascular diseases, cancer, and other major human diseases, suggesting that autophagy could be a candidate therapeutic target for NCDs. Natural products/phytochemicals are important resources for drugs against a wide variety of diseases. Recently, compounds from natural plants, such as resveratrol, curcumin, and ursolic acid, have been recognized as promising autophagy modulators. In this review, we address recent advances and the current status of the development of natural autophagy modulators in NCDs and provide an update of the latest in vitro and in vivo experiments that pave the way to clinical studies. Specifically, we focus on the relationship between natural autophagy modulators and NCDs, with an intent to identify natural autophagy modulators with therapeutic potential.
非传染性疾病（NCDs）被定义为一类与不良行为和生活方式密切相关的疾病，例如心血管疾病、癌症和糖尿病。在人口增长和老龄化的推动下，非传染性疾病已成为全球最大的疾病负担，因此迫切需要预防和控制这些慢性病。自噬是一个进化上保守的过程，它在溶酶体中降解细胞衰老或功能失调的细胞器。越来越多的证据表明自噬在心血管疾病、癌症和其他主要人类疾病的发病机制中起主要作用，这表明自噬可能是治疗非传染性疾病的一个候选靶点。天然产物/植物化学物质是对抗多种疾病药物的重要资源。最近，来自天然植物的化合物，如白藜芦醇、姜黄素和熊果酸，已被认为是有前景的自噬调节剂。在这篇综述中，我们阐述了天然自噬调节剂在非传染性疾病研究中的最新进展和发展现状，并提供了最新的体外和体内实验进展，为临床研究铺平道路。具体来说，我们关注天然自噬调节剂与非传染性疾病之间的关系，旨在确定具有治疗潜力的天然自噬调节剂。
