Linge H, Nevermann N, Schmelzle M, Quante M
Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.
Chirurgie (Heidelb). 2024 Sep;95(9):715-720. doi: 10.1007/s00104-024-02139-1. Epub 2024 Aug 1.
Gender-specific differences in hepatobiliary and transplantation surgery are decisive for the diagnosis, treatment and long-term outcomes. Men exhibit a higher risk of late recurrences and cancer-specific death after liver cancer resection. The emphasis on screening recommendations and ensuring equal access to treatment options are vital to minimize disparities. In kidney and liver transplantations, women are less frequently listed and endure longer waiting times, while men dominate the waiting list. Gender-specific disparities in drug compatibility necessitate differentiated dosing. Further studies are needed to ensure equity in transplantation treatment. Individualized treatment considering these differences can enhance treatment outcomes and the quality of life of patients.
肝胆与移植手术中的性别差异对诊断、治疗及长期预后具有决定性意义。男性在肝癌切除术后出现晚期复发和癌症特异性死亡的风险更高。强调筛查建议并确保平等获得治疗方案对于减少差异至关重要。在肾移植和肝移植中,女性被列入等待名单的频率较低且等待时间更长,而男性在等待名单中占主导地位。药物兼容性方面的性别差异需要差异化给药。需要进一步研究以确保移植治疗的公平性。考虑这些差异的个体化治疗可以提高治疗效果和患者的生活质量。