Lourme J, Dessaint J P, Capron A
Pathol Biol (Paris). 1985 Sep;33(7):735-40.
A statistical analysis is performed on the results of 881 determinations of thyroglobulin antibodies in humans. Antibodies were assayed comparatively by radioimmunoassay using a sandwich method and by tanned red cell haemagglutination. A very good concordance was found between the two techniques, apart from the low titer zone. A significant correlation was observed between on the one side, the radioactivity index of the diluted serum, defined as the increment of radioactivity bound by undiluted patient serum over the positive threshold, divided by this threshold, and, on the other side, the antibody titer, i.e. the reciprocal of the highest serum dilution superior to the positive threshold by radioimmunoassay. The corresponding linear regression allows to define a arbitrary unit system which associates values of the radioactivity index with an average antibody titer.
对881例人体甲状腺球蛋白抗体测定结果进行了统计分析。采用夹心放射免疫分析法和鞣酸红细胞血凝法对抗体进行了比较检测。除低滴度区外，两种技术之间具有很好的一致性。一方面，稀释血清的放射性指数定义为未稀释患者血清结合的放射性超过阳性阈值的增量除以该阈值，另一方面，抗体滴度，即放射免疫分析法中高于阳性阈值的最高血清稀释倍数的倒数，二者之间观察到显著相关性。相应的线性回归允许定义一个任意单位系统，该系统将放射性指数值与平均抗体滴度相关联。
