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解偶联蛋白 2 在肾脏疾病中的作用及信号通路。

Emerging role and the signaling pathways of uncoupling protein 2 in kidney diseases.

机构信息

Department of Pediatrics, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Ren Fail. 2024 Dec;46(2):2381604. doi: 10.1080/0886022X.2024.2381604. Epub 2024 Aug 1.

DOI:10.1080/0886022X.2024.2381604
PMID:39090967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11299446/
Abstract

OBJECTIVES

Uncoupling protein 2 (UCP2) was involved in the pathogenesis and development of kidney diseases. Many signaling pathways and factors regulate the expression of UCP2. We aimed to investigate the precise role of UCP2 and its signaling pathways in kidney diseases.

METHODS

We summarized the available evidence to yield a more detailed conclusion of the signal transduction pathways of UCP2 and its role in the development and progression of kidney diseases.

RESULTS

UCP2 could interact with 14.3.3 family proteins, mitochondrial phospholipase iPLA2γ, NMDAR, glucokinase, PPARγ2. There existed a signaling pathway between UCP2 and NMDAR, PPARγ. UCP2 can inhibit the ROS production, inflammatory response, and apoptosis, which may protect against renal injury, particularly AKI. Meanwhile UCP2 can decrease ATP production and inhibit the secretion of insulin, which may alleviate chronic renal damages, such as diabetic nephropathy and kidney fibrosis.

CONCLUSIONS

Homeostasis of UCP2 is helpful for kidney health. UCP2 may play different roles in different kinds of renal injury.

摘要

目的

解偶联蛋白 2（UCP2）参与了肾脏疾病的发病机制和发展。许多信号通路和因素调节 UCP2 的表达。我们旨在研究 UCP2 及其信号通路在肾脏疾病中的确切作用。

方法

我们总结了现有证据，以更详细地得出 UCP2 的信号转导通路及其在肾脏疾病发展和进展中的作用的结论。

结果

UCP2 可以与 14.3.3 家族蛋白、线粒体磷酸酶 iPLA2γ、NMDAR、葡激酶、PPARγ2 相互作用。UCP2 与 NMDAR、PPARγ 之间存在信号通路。UCP2 可以抑制 ROS 产生、炎症反应和细胞凋亡，从而可能对肾脏损伤（特别是急性肾损伤）起到保护作用。同时，UCP2 可以减少 ATP 产生并抑制胰岛素分泌，从而可能减轻慢性肾脏损伤，如糖尿病肾病和肾脏纤维化。

结论

UCP2 的平衡有助于肾脏健康。UCP2 在不同类型的肾脏损伤中可能发挥不同的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11299446/cf06edd9d51e/IRNF_A_2381604_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11299446/ad8bdcfcd733/IRNF_A_2381604_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11299446/cf06edd9d51e/IRNF_A_2381604_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11299446/ad8bdcfcd733/IRNF_A_2381604_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11299446/cf06edd9d51e/IRNF_A_2381604_F0002_C.jpg

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