Antonelli Incalzi R, Maini C L, Bonetti M G, Pistelli R, Valle G
Nuklearmedizin. 1985 Aug;24(4):180-4.
The degree of permeability of the alveolar-capillary barrier to low molecular weight solutes has been supposed to depend upon the radius of the epithelial pores. The bullous emphysema is a natural model in which this radius may increase because of the high tension in the bulla. Accordingly, the 99mTc-DTPA clearance may be expected to be faster than normal in lung fields including bullae. Results of the present study in which 99mTc-DTPA clearance was measured in six patients with bullous emphysema, seem to confirm this hypothesis at least to some extent. In fact, either increased or normal 99mTc-DTPA clearances were found over the lung fields including bullae communicating with the bronchial tree. Differences in both the size and the inner tension of the bullae as well as in the anatomical and functional conditions of the surrounding parenchyma are likely to account for such varying behaviour.
肺泡-毛细血管屏障对低分子量溶质的通透程度被认为取决于上皮孔的半径。大疱性肺气肿是一种自然模型，其中由于大疱内的高张力，该半径可能会增加。因此，在包括大疱的肺野中，预计99mTc-DTPA清除率会比正常情况更快。本研究对6例大疱性肺气肿患者进行了99mTc-DTPA清除率测量，其结果似乎至少在一定程度上证实了这一假设。事实上，在与支气管树相通的包括大疱的肺野中，发现99mTc-DTPA清除率要么增加，要么正常。大疱的大小和内部张力以及周围实质的解剖和功能状况的差异可能是造成这种不同表现的原因。
