Division of Hematology/Oncology, Early Phase Clinical Research Program, Jonsson Comprehensive Cancer at UCLA, David Geffen School of Medicine, UCLA, Los Angeles, California.
Cancer Discov. 2024 Aug 2;14(8):1369-1371. doi: 10.1158/2159-8290.CD-24-0771.
In this issue, Picco and colleagues provide further evidence that WRN inhibitors are synthetically lethal in microsatellite instability-high (MSI-H) cancers and function by blocking the helicase domain of select WRN residues. They demonstrate that WRN inhibitors may be even more effective in a subset of MSI-high tumors with (TA)n repeat expansions, which represents a possible strategy in clinical development. See related article by Picco et al., p. 1457 (1).
在本期中，Picco 及其同事提供了进一步的证据表明，WRN 抑制剂在微卫星不稳定高（MSI-H）癌症中具有合成致死性，并通过阻断选择性 WRN 残基的解旋酶结构域发挥作用。他们表明，WRN 抑制剂在具有（TA）n 重复扩展的 MSI 高肿瘤亚组中可能更有效，这代表了临床开发中的一种可能策略。请参阅 Picco 等人的相关文章，第 1457 页（1）。
