Jalili Mahdiehsadat, Azizi Reyhaneh, Aflatoonian Abbas, Ghadiri-Anari Akram
Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Reprod Biomed. 2024 Jul 8;22(5):357-362. doi: 10.18502/ijrm.v22i5.16434. eCollection 2024 May.
Since thyroid hormones have an essential role in energy production, early development of the human placenta, embryo development, and implantation, abnormalities in thyroid function can significantly affect pregnancy outcomes.
The present study aimed to investigate the effect of higher thyroid-stimulating hormone (TSH) levels in the normal range in euthyroid women with unexplained infertility.
In this cross-sectional study, we evaluated the data for 300 euthyroid women aged between 18 and 39 yr with normal TSH levels ( 5 mIU/L) referred to Yazd Reproductive Sciences Institute, Yazd, Iran from December 2018-March 2021 in 2 groups: the case group (with unexplained infertility) and the control group (with male factor infertility). Finally, age, body mass index, and serum levels of TSH were extracted from participants' medical records and compared between groups.
The mean age and TSH level of participants were 31.52 3.52 yr and 1.24 2.59 mIU/L, respectively. 142 women (47.3%) had TSH 2.5, and 158 women (52.7%) had TSH 2.5 mIU/L. The women with unexplained infertility had significantly higher TSH levels than controls in the same normal range (0.62 vs. 0.64 mIU/L, p 0.001). Although a more significant proportion of women in the case group had TSH levels 2.5 mIU/L, we did not find a significant association between TSH levels and age or body mass index.
Women with unexplained infertility have a higher level of serum TSH in the normal range ( 2.5 mIU/L) than the control group. So, the effect of TSH treatment on these women should be considered.
由于甲状腺激素在能量产生、人类胎盘早期发育、胚胎发育和着床过程中发挥着重要作用，甲状腺功能异常会显著影响妊娠结局。
本研究旨在探讨甲状腺功能正常但促甲状腺激素（TSH）水平处于正常范围内较高值的不明原因不孕症女性的情况。
在这项横断面研究中，我们评估了2018年12月至2021年3月期间转诊至伊朗亚兹德生殖科学研究所的300名年龄在18至39岁之间、TSH水平正常（≤5 mIU/L）的甲状腺功能正常女性的数据，分为两组：病例组（不明原因不孕症）和对照组（男性因素不孕症）。最后，从参与者的病历中提取年龄、体重指数和血清TSH水平，并在组间进行比较。
参与者的平均年龄和TSH水平分别为31.52±3.52岁和1.24±2.59 mIU/L。142名女性（47.3%）的TSH≤2.5，158名女性（52.7%）的TSH＞2.5 mIU/L。在相同的正常范围内，不明原因不孕症女性的TSH水平显著高于对照组（0.62对0.64 mIU/L，p＜0.001）。尽管病例组中TSH水平＞2.5 mIU/L的女性比例更高，但我们未发现TSH水平与年龄或体重指数之间存在显著关联。
不明原因不孕症女性在正常范围（≤2.5 mIU/L）内的血清TSH水平高于对照组。因此，应考虑TSH治疗对这些女性的影响。
