• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

解决弥漫性脑桥内在型胶质瘤的障碍：脂质纳米颗粒药物递送的变革性作用。

Addressing barriers in diffuse intrinsic pontine glioma: the transformative role of lipid nanoparticulate drug delivery.

作者信息

Presswala Zenab, Acharya Sheetal, Shah Shreeraj

机构信息

Department of Pharmaceutical Technology, L.J Institute of Pharmacy, Lok Jagruti University, L.J Campus, Near Sarkhej-Sanand Circle, Off. S.G. Road, Ahmedabad-382 210, India.

出版信息

ADMET DMPK. 2024 Jul 23;12(3):403-429. doi: 10.5599/admet.2214. eCollection 2024.

DOI:10.5599/admet.2214
PMID:39091904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11289511/
Abstract

BACKGROUND AND PURPOSE

The brainstem tumour known as diffuse intrinsic pontine glioma (DIPG), also known as pontine glioma, infiltrative brainstem glioma is uncommon and virtually always affects children. A pontine glioma develops in the brainstem's most vulnerable region (the "pons"), which regulates a number of vital processes like respiration and blood pressure. It is particularly challenging to treat due to its location and how it invades healthy brain tissue. The hunt for a solution is continually advancing thanks to advances in modern medicine, but the correct approach is still elusive. With a particular focus on brain tumours that are incurable or recur, research is ongoing to discover fresh, practical approaches to target particular areas of the brain.

EXPERIMENTAL APPROACH

To successfully complete this task, a thorough literature search was carried out in reputable databases like Google Scholar, PubMed, and ScienceDirect.

KEY RESULTS

The present article provides a comprehensive analysis of the notable advantages of lipid nanoparticles compared to alternative nanoparticle formulations. The article delves into the intricate realm of diverse lipid-based nanoparticulate delivery systems, which are used in Diffuse Intrinsic Pontine Glioma (DIPG) which thoroughly examines preclinical and clinical studies, providing a comprehensive analysis of the effectiveness and potential of lipid nanoparticles in driving therapeutic advancements for DIPG.

CONCLUSION

There is strong clinical data to support the promising method of using lipid-based nanoparticulate drug delivery for brain cancer treatment, which shows improved outcomes.

摘要

背景与目的

脑干肿瘤即弥漫性固有脑桥胶质瘤（DIPG），也被称为脑桥胶质瘤、浸润性脑干胶质瘤，较为罕见，几乎总是发生在儿童身上。脑桥胶质瘤发生于脑干最脆弱的区域（“脑桥”），该区域调节呼吸和血压等多项重要生理过程。由于其位置以及对健康脑组织的侵袭方式，治疗极具挑战性。尽管现代医学取得了进展，寻找解决方案的工作仍在不断推进，但正确的方法仍难以捉摸。尤其针对无法治愈或复发的脑肿瘤，正在开展研究以发现针对大脑特定区域的新的实用方法。

实验方法

为成功完成这项任务，在谷歌学术、PubMed和ScienceDirect等知名数据库中进行了全面的文献检索。

关键结果

本文全面分析了脂质纳米颗粒相较于其他纳米颗粒制剂的显著优势。文章深入探讨了多种基于脂质的纳米颗粒递送系统的复杂领域，这些系统用于弥漫性固有脑桥胶质瘤（DIPG），全面审视了临床前和临床研究，对脂质纳米颗粒在推动DIPG治疗进展方面的有效性和潜力进行了全面分析。

结论

有强有力的临床数据支持使用基于脂质的纳米颗粒药物递送治疗脑癌这一前景广阔的方法，该方法显示出更好的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/72e26471edc1/ADMET-12-2214-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/245d0982e3a3/ADMET-12-2214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/6d4ef718e1a3/ADMET-12-2214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/8c1433884d24/ADMET-12-2214-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/ac37d9b829ef/ADMET-12-2214-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/e7f76fafadad/ADMET-12-2214-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/78911bcada3d/ADMET-12-2214-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/acedbcb44450/ADMET-12-2214-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/904ef1888a5d/ADMET-12-2214-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/bf6e3caecb56/ADMET-12-2214-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/b60d8db7ea65/ADMET-12-2214-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/88904a647d29/ADMET-12-2214-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/e14195ae7251/ADMET-12-2214-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/72e26471edc1/ADMET-12-2214-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/245d0982e3a3/ADMET-12-2214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/6d4ef718e1a3/ADMET-12-2214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/8c1433884d24/ADMET-12-2214-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/ac37d9b829ef/ADMET-12-2214-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/e7f76fafadad/ADMET-12-2214-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/78911bcada3d/ADMET-12-2214-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/acedbcb44450/ADMET-12-2214-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/904ef1888a5d/ADMET-12-2214-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/bf6e3caecb56/ADMET-12-2214-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/b60d8db7ea65/ADMET-12-2214-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/88904a647d29/ADMET-12-2214-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/e14195ae7251/ADMET-12-2214-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb5/11289511/72e26471edc1/ADMET-12-2214-g013.jpg

相似文献

1
Addressing barriers in diffuse intrinsic pontine glioma: the transformative role of lipid nanoparticulate drug delivery.解决弥漫性脑桥内在型胶质瘤的障碍：脂质纳米颗粒药物递送的变革性作用。
ADMET DMPK. 2024 Jul 23;12(3):403-429. doi: 10.5599/admet.2214. eCollection 2024.
2
Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma.脂质体阿霉素对流增强递送治疗小儿弥漫性脑桥内在型胶质瘤和丘脑高级别胶质瘤的临床前评估
J Neurosurg Pediatr. 2017 May;19(5):518-530. doi: 10.3171/2016.9.PEDS16152. Epub 2017 Feb 17.
3
Current status and advances to improving drug delivery in diffuse intrinsic pontine glioma.弥漫性内生性桥脑胶质瘤药物递送的现状和进展。
J Control Release. 2024 Jun;370:835-865. doi: 10.1016/j.jconrel.2024.05.018. Epub 2024 May 20.
4
MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma.MRI 引导聚焦超声增强实验性弥漫性内在脑桥胶质瘤的药物递送。
J Control Release. 2021 Feb 10;330:1034-1045. doi: 10.1016/j.jconrel.2020.11.010. Epub 2020 Nov 11.
5
Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma.弥漫性脑桥内在型胶质瘤的临床前模型
Front Oncol. 2015 Jul 24;5:172. doi: 10.3389/fonc.2015.00172. eCollection 2015.
6
Clinical experience of convection-enhanced delivery (CED) of carboplatin and sodium valproate into the pons for the treatment of diffuse intrinsic pontine glioma (DIPG) in children and young adults after radiotherapy.经颅直流电刺激治疗精神分裂症的研究进展
Int J Clin Oncol. 2021 Apr;26(4):647-658. doi: 10.1007/s10147-020-01853-0. Epub 2021 Feb 11.
7
Leptomeningeal and subependymal seeding of diffuse intrinsic pontine glioma: a case report.弥漫性内生桥脑胶质瘤的软脑膜和室管膜播散：一例报告。
Childs Nerv Syst. 2022 Aug;38(8):1643-1645. doi: 10.1007/s00381-022-05482-y. Epub 2022 Mar 15.
8
Decreased natural killer cells in diffuse intrinsic pontine glioma patients.弥漫性脑桥固有胶质瘤患者自然杀伤细胞减少。
Childs Nerv Syst. 2020 Jul;36(7):1345-1346. doi: 10.1007/s00381-020-04665-9. Epub 2020 May 16.
9
Progress in diffuse intrinsic pontine glioma: advocating for stereotactic biopsy in the standard of care.弥漫性内生脑桥胶质瘤的研究进展：提倡在标准治疗中进行立体定向活检。
Neurosurg Focus. 2020 Jan 1;48(1):E4. doi: 10.3171/2019.9.FOCUS19745.
10
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma.逆转癌症基因表达可鉴定弥漫性内生脑桥胶质瘤的再利用药物。
Acta Neuropathol Commun. 2022 Oct 23;10(1):150. doi: 10.1186/s40478-022-01463-z.

本文引用的文献

1
Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review.纳米材料作为克服血脑屏障的药物递送剂：综述
ADMET DMPK. 2023 Oct 31;12(1):63-105. doi: 10.5599/admet.2043. eCollection 2024.
2
Quality by design engineered, enhanced anticancer activity of temozolomide and resveratrol coloaded NLC and brain targeting via lactoferrin conjugation in treatment of glioblastoma.通过设计质量工程，增强了替莫唑胺和白藜芦醇共载纳米脂质载体的抗癌活性，并通过乳铁蛋白偶联实现脑靶向，用于治疗胶质母细胞瘤。
Eur J Pharm Biopharm. 2023 Oct;191:175-188. doi: 10.1016/j.ejpb.2023.08.018. Epub 2023 Aug 28.
3
Solid Lipid Nanoparticles for Drug Delivery.
固体脂质纳米粒用于药物传递。
Methods Mol Biol. 2023;2622:139-146. doi: 10.1007/978-1-0716-2954-3_12.
4
Intranasal delivery of nanoliposomal SN-38 for treatment of diffuse midline glioma.用于治疗弥漫性中线胶质瘤的纳米脂质体SN-38经鼻给药
J Neurosurg. 2022 Nov 11;138(6):1570-1579. doi: 10.3171/2022.9.JNS22715. Print 2023 Jun 1.
5
Bioconjugate-loaded solid lipid nanoparticles for enhanced anticancer drug delivery to brain cancer cells: An evaluation.载药的固体脂质纳米粒用于增强抗癌药物向脑癌细胞的递送：评价。
Indian J Med Res. 2022 Jul;156(1):139-148. doi: 10.4103/ijmr.IJMR_514_19.
6
Berberine and folic acid co-modified pH-sensitive cascade-targeted PTX-liposomes coated with Tween 80 for treating glioma.表没食子儿茶素没食子酸酯和叶酸共修饰的 pH 敏感级联靶向紫杉醇脂质体，并用吐温 80 包被，用于治疗神经胶质瘤。
Bioorg Med Chem. 2022 Sep 1;69:116893. doi: 10.1016/j.bmc.2022.116893. Epub 2022 Jun 20.
7
Emerging nanomedical strategies for direct targeting of pediatric and adult diffuse gliomas.新兴纳米医学策略在小儿和成人弥漫性神经胶质瘤中的直接靶向治疗。
Br J Cancer. 2022 Oct;127(7):1193-1200. doi: 10.1038/s41416-022-01884-6. Epub 2022 Jun 17.
8
Targeted liposomes for combined delivery of artesunate and temozolomide to resistant glioblastoma.用于将青蒿琥酯和替莫唑胺联合递送至耐药性胶质母细胞瘤的靶向脂质体。
Biomaterials. 2022 Aug;287:121608. doi: 10.1016/j.biomaterials.2022.121608. Epub 2022 Jun 1.
9
In situ targeting nanoparticles-hydrogel hybrid system for combined chemo-immunotherapy of glioma.原位靶向纳米粒-水凝胶杂化系统用于脑胶质瘤的联合化疗-免疫治疗。
J Control Release. 2022 May;345:786-797. doi: 10.1016/j.jconrel.2022.03.050. Epub 2022 Mar 31.
10
Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers.通过双重靶向纳米结构脂质载体增强硼替佐米的 BBB 和 BBTB 穿透性并改善抗脑胶质瘤作用。
J Control Release. 2022 May;345:371-384. doi: 10.1016/j.jconrel.2022.03.019. Epub 2022 Mar 15.