Zhang Yuan-Yuan, Jiang Xu-Hong, Zhu Pei-Pei, Zhuo Wen-Yan, Liu Li-Bin
Department of Neurology, Zhuhai People's Hospital, Zhuhai, Guangdong, China.
Department of Health Management, Zhuhai People's Hospital, Zhuhai, Guangdong, China.
Front Neurol. 2024 Jul 18;15:1407860. doi: 10.3389/fneur.2024.1407860. eCollection 2024.
Amidst rising Parkinson's disease (PD) incidence in an aging global population, the need for non-invasive and reliable diagnostic methods is increasingly critical. This review evaluates the strategic role of transcranial sonography (TCS) in the early detection and monitoring of PD. TCS's ability to detect substantia nigra hyperechogenicity offers profound insights into its correlation with essential neuropathological alterations-namely, iron accumulation, neuromelanin depletion, and glial proliferation-fundamental to PD's pathophysiology. Our analysis highlights TCS's advantages, including its non-invasiveness, cost-effectiveness, and ease of use, positioning it as an invaluable tool for early diagnosis and continual disease progression monitoring. Moreover, TCS assists in identifying potential risk and protective factors, facilitating tailored therapeutic strategies to enhance clinical outcomes. This review advocates expanding TCS utilization and further research to maximize its diagnostic and prognostic potential in PD management, contributing to a more nuanced understanding of the disease.
在全球人口老龄化导致帕金森病（PD）发病率不断上升的背景下，对非侵入性且可靠的诊断方法的需求日益迫切。本综述评估了经颅超声检查（TCS）在PD早期检测和监测中的战略作用。TCS检测黑质高回声性的能力为其与PD病理生理学基础的重要神经病理学改变（即铁蓄积、神经黑色素耗竭和胶质细胞增殖）之间的相关性提供了深刻见解。我们的分析强调了TCS的优势，包括其非侵入性、成本效益和易用性，使其成为早期诊断和持续疾病进展监测的宝贵工具。此外，TCS有助于识别潜在的风险和保护因素，促进制定个性化治疗策略以改善临床结果。本综述主张扩大TCS的应用并开展进一步研究，以最大限度地发挥其在PD管理中的诊断和预后潜力，有助于对该疾病有更细致入微的理解。
