Wang Yaxuan, Qi Guoyan, Yang Ying, Yang Hongxia
Yaxuan Wang, Department of Oncology, Hebei Medical University, Shijiazhuang 050017, Hebei, China.
Guoyan Qi, Department of Oncology, Hebei Medical University, Shijiazhuang 050017, Hebei, China. Hebei Provincial Key Laboratory of Myasthenia Gravis, Shijiazhuang 050030, Hebei, China.
Pak J Med Sci. 2024 Aug;40(7):1384-1390. doi: 10.12669/pjms.40.7.8698.
To explore the clinical features of thymoma with and without myasthenia gravis (MG).
This was a retrospective study. Two hundred and thirty-three patients with mediastinal masses who were initially diagnosed in People's Hospital of Shijiazhuang, China, between January 2014 and June 2022 and had complete clinical data and underwent surgical treatment at People's Hospital of Shijiazhuang were retrospectively analyzed.
The age of patients with thymoma alone was significantly older than that of thymoma patients complicated with MG. The number of female patients was slightly more than males for both groups. Proportions of type A, AB, B1, B2, and B3 thymomas in Group-A were 0.77, 11.54, 11.51, 33.85, and 31.54%, respectively, and the proportions in Group-B were 9.68, 22.58, 12.90, 32.26, and 22.58%. The size of tumors in patients with thymoma alone was larger than that of patients with thymoma complicated with MG. The proportion of patients with tumor size of more than 10 cm in the thymoma alone group was significantly higher than that in the MG group. There were no relapses in patients with type A disease and relapses were noted in a few patients with type B1, B2 and B3 diseases. The same survival rates were reported for the two groups.
MG rarely occurs in type A and type C diseases. The prognosis of thymoma with MG is similar to that of thymoma alone. The main causes of death may be myasthenia crisis in thymoma patients with MG and advanced tumor stage in patients with thymoma alone.
探讨伴或不伴重症肌无力（MG）的胸腺瘤的临床特征。
本研究为回顾性研究。对2014年1月至2022年6月在中国石家庄市人民医院初诊、临床资料完整且在石家庄市人民医院接受手术治疗的233例纵隔肿物患者进行回顾性分析。
单纯胸腺瘤患者的年龄显著大于合并MG的胸腺瘤患者。两组女性患者数量均略多于男性。A组中A型、AB型、B1型、B2型和B3型胸腺瘤的比例分别为0.77%、11.54%、11.51%、33.85%和31.54%，B组中相应比例分别为9.68%、22.58%、12.90%、32.26%和22.58%。单纯胸腺瘤患者的肿瘤大小大于合并MG的胸腺瘤患者。单纯胸腺瘤组中肿瘤大小超过10 cm的患者比例显著高于MG组。A型疾病患者无复发，B1型、B2型和B3型疾病的少数患者有复发。两组报告的生存率相同。
MG很少发生于A型和C型疾病。合并MG的胸腺瘤的预后与单纯胸腺瘤相似。主要死亡原因可能是合并MG的胸腺瘤患者发生肌无力危象，以及单纯胸腺瘤患者肿瘤分期较晚。
