Soleimani Laili, Ouyang Yuxia, Cho Sunghye, Kia Arash, Beeri Michal Schnaider, Lin Hung-Mo, Ravona-Springer Ramit, Ramsingh Nadia, Liberman Mark Y, Grossman Murray, Nevler Naomi
Icahn School of Medicine at Mount Sinai New York New York USA.
Linguistic Data Consortium University of Pennsylvania Philadelphia Pennsylvania USA.
Alzheimers Dement (Amst). 2024 Aug 1;16(3):e12604. doi: 10.1002/dad2.12604. eCollection 2024 Jul-Sep.
Depression and its components significantly impact dementia prediction and severity, necessitating reliable objective measures for quantification.
We investigated associations between emotion-based speech measures (valence, arousal, and dominance) during picture descriptions and depression dimensions derived from the geriatric depression scale (GDS, dysphoria, withdrawal-apathy-vigor (WAV), anxiety, hopelessness, and subjective memory complaint).
Higher WAV was associated with more negative valence (estimate = -0.133, = 0.030). While interactions of apolipoprotein E (APOE) 4 status with depression dimensions on emotional valence did not reach significance, there was a trend for more negative valence with higher dysphoria in those with at least one APOE4 allele (estimate = -0.404, = 0.0846). Associations were similar irrespective of dementia severity.
Our study underscores the potential utility of speech biomarkers in characterizing depression dimensions. In future research, using emotionally charged stimuli may enhance emotional measure elicitation. The role of APOE on the interaction of speech markers and depression dimensions warrants further exploration with greater sample sizes.
Participants reporting higher apathy used more negative words to describe a neutral picture.Those with higher dysphoria and at least one APOE4 allele also tended to use more negative words.Our results suggest the potential use of speech biomarkers in characterizing depression dimensions.
抑郁症及其组成部分对痴呆症的预测和严重程度有显著影响，因此需要可靠的客观测量方法进行量化。
我们调查了在描述图片过程中基于情绪的语音测量指标（效价、唤醒度和优势度）与老年抑郁量表（GDS）得出的抑郁维度（烦躁不安、退缩-冷漠-活力（WAV）、焦虑、绝望和主观记忆抱怨）之间的关联。
较高的WAV与更消极的效价相关（估计值=-0.133，P=0.030）。虽然载脂蛋白E（APOE）4状态与抑郁维度在情绪效价上的相互作用未达到显著水平，但在至少有一个APOE4等位基因的人群中存在一种趋势，即烦躁不安程度越高，效价越消极（估计值=-0.404，P=0.0846）。无论痴呆症严重程度如何，关联情况相似。
我们的研究强调了语音生物标志物在表征抑郁维度方面的潜在效用。在未来的研究中，使用带有情感的刺激可能会增强对情绪测量指标的诱发效果。APOE在语音标记物与抑郁维度相互作用中的作用值得用更大样本量进一步探索。
报告冷漠程度较高的参与者在描述中性图片时使用了更多消极词汇。烦躁不安程度较高且至少有一个APOE4等位基因的人也倾向于使用更多消极词汇。我们的结果表明语音生物标志物在表征抑郁维度方面具有潜在用途。
