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水提取物对大鼠四氯化碳诱导的肝细胞损伤的保肝活性。

Hepatoprotective activity of aqueous extract against hepatocellular damage induced by CCL in rats.

作者信息

Ferdjioui Siham, Belhattab Rachid, Ouhida Soraya, Khither Hanane, Saoudi Soulef, Mayouf Nozha

机构信息

Department of Biochemistry, Laboratory of Applied Microbiology, University Ferhat Abbas Setif-1, Setif, Algeria.

Pathologic anatomy laboratory CHU Saadna Abdennour, faculty of medicine, University Ferhat Abbas Setif 1, Setif, Algeria.

出版信息

Nat Prod Res. 2024 Aug 2:1-6. doi: 10.1080/14786419.2024.2387252.


DOI:10.1080/14786419.2024.2387252
PMID:39092521
Abstract

This study aims to assess hepatoprotective properties of . Decoction was used to prepare the aqueous extract. The preliminary cytotoxicity evaluated against Caco 2 and RAW 264 cells demonstrate no cytotoxic effect. The preventive impact of the extract against liver damage was evaluated by examining blood levels of AST, ALT, ALP, total proteins, and histological alterations in liver tissues. Thirty albino rats were separated into five groups: the first served as normal group, the second was injected by olive oil (3 ml/kg), and the third was injected by CCL (3 ml/kg). However, groups IV and V received daily doses of 250 and 500 mg extract/kg bw, respectively before CCL injection. The results showed that the administration of the extract led to a marked improvement in plasma biochemical markers and a reduction in symptoms of CCL4-induced liver damage. The extract exhibits hepatoprotective activity, which may be attributed to its phytochemical components.

摘要

本研究旨在评估……的保肝特性。采用水煎煮法制备水提取物。对Caco 2和RAW 264细胞进行的初步细胞毒性评估显示无细胞毒性作用。通过检测血液中AST、ALT、ALP、总蛋白水平以及肝组织的组织学改变,评估提取物对肝损伤的预防作用。将30只白化大鼠分为五组:第一组作为正常组,第二组注射橄榄油(3毫升/千克),第三组注射四氯化碳(3毫升/千克)。然而,第四组和第五组在注射四氯化碳前,分别每天给予250和500毫克提取物/千克体重的剂量。结果表明,提取物的给药导致血浆生化指标显著改善,并减轻了四氯化碳诱导的肝损伤症状。该提取物具有保肝活性,这可能归因于其植物化学成分。

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引用本文的文献

[1]
Antioxidant, Phytochemical, and Pharmacological Properties of Algerian Extracts.

Antioxidants (Basel). 2024-12-11

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