Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
J Neurochem. 2024 Oct;168(10):3361-3364. doi: 10.1111/jnc.16192. Epub 2024 Aug 2.
This preface introduces the Special Issue on Neuroimmunology in the Journal of Neurochemistry. The basis of neuroimmunology is to understand functional interactions between cells of the immune system and the central nervous system (CNS). These cells communicate across systems because they share signaling molecules and corresponding receptors. Moreover, this cell signaling allows for dynamic bidirectional communication between the immune system and the brain both within the CNS proper as well as across peripheral organs. Because of this, Neuroimmunology intersects with many biological processes including immunity, behavior, endocrinology, metabolism, and pathology. Understanding neuroimmune interactions that influence CNS homeostasis is especially relevant in health and disease. This special issue comprises of 14 articles, representing 9 review articles and 5 original articles, covering the roles of neuroimmunology relevant to CNS injury, CNS & peripheral infections, cancer, Alzheimer's disease, and COVID-19. Thus, these articles highlight different aspects of neuroimmunology and signaling, and represent progress in understanding the consequences of inflammation on key communication pathways between the immune system and the brains.
这篇序言介绍了《神经化学杂志》上的神经免疫学特刊。神经免疫学的基础是了解免疫系统细胞和中枢神经系统（CNS）之间的功能相互作用。这些细胞通过共享信号分子和相应的受体在系统间进行通讯。此外，这种细胞信号传导允许免疫系统和大脑之间在中枢神经系统内部以及穿过外周器官进行动态的双向通讯。因此，神经免疫学与包括免疫、行为、内分泌、代谢和病理学在内的许多生物学过程相交织。了解影响中枢神经系统内稳态的神经免疫相互作用在健康和疾病中尤为重要。本期特刊由 14 篇文章组成，其中包括 9 篇综述文章和 5 篇原始研究文章，涵盖了与中枢神经系统损伤、中枢神经系统和外周感染、癌症、阿尔茨海默病和 COVID-19 相关的神经免疫学作用。因此，这些文章突出了神经免疫学和信号转导的不同方面，代表了对炎症对免疫系统和大脑之间关键通讯途径的影响的理解的进展。
