Department of Pediatrics, Division of Pediatric Intensive Care, University of Health Sciences, Istanbul Kanuni Sultan Suleyman Research and Training Hospital, Istanbul, Turkey.
Istanbul Kanuni Sultan Suleyman Research and Training Hospital, Department of Pediatrics, Division of Neonatology Istanbul, University of Health Sciences, Istanbul, Turkey.
J Clin Apher. 2024 Aug;39(4):e22142. doi: 10.1002/jca.22142.
Acute cerebellitis is a rare complication of pediatric infections. There are many reports that viral infections lead to neurological manifestations, including acute cerebellitis.
A retrospective chart review was conducted for pediatric patients diagnosed with enterovirus cerebellitis between 2000 and 2024. The methods involved reviewing clinical and radiological records and assessing the treatment methods.
Case Report We present the case of a 4-year-old immunocompetent child who initially presented with acute encephalopathy followed by truncal ataxia, and eventually received a diagnosis of postinfectious cerebellitis. Enterovirus real-time polymerase chain reaction were positive in the nasopharyngeal swab. Therapeutic plasma exchange (TPE) was started due to neurological deterioration despite IVIG treatment. She improved significantly with TPE, and methylprednisolone treatment and was discharged in good health status. The patient is being followed up as neurologically normal.
Acute cerebellitis associated with enterovirus is a rare pediatric disorder. Early diagnosis and treatment with TPE in this severe case is thought to be preventive for the potentially fatal complications.
急性小脑炎是儿科感染的罕见并发症。有许多报道称病毒感染可导致包括急性小脑炎在内的神经表现。
对 2000 年至 2024 年间诊断为肠道病毒小脑炎的儿科患者进行回顾性图表审查。方法包括回顾临床和影像学记录，并评估治疗方法。
病例报告我们报告了一例 4 岁免疫功能正常的儿童，最初表现为急性脑病，随后出现躯干共济失调，最终被诊断为感染后小脑炎。鼻咽拭子中肠道病毒实时聚合酶链反应阳性。尽管进行了 IVIG 治疗，但由于神经恶化，开始进行治疗性血浆置换 (TPE)。她的病情在 TPE 治疗后显著改善，并接受了甲基强的松龙治疗，出院时身体状况良好。患者正在接受神经正常的随访。
与肠道病毒相关的急性小脑炎是一种罕见的儿科疾病。在这种严重情况下，早期诊断和 TPE 治疗被认为可预防潜在的致命并发症。
