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门诊中帕金森病患者的建议:直立性低血压。

Advice to People with Parkinson's in My Clinic: Orthostatic Hypotension.

机构信息

Department of Neurology, University of Utah, Salt Lake City, UT, USA.

George E. Wahlen VA Medical Center, Salt Lake City, UT, USA.

出版信息

J Parkinsons Dis. 2024;14(6):1139-1146. doi: 10.3233/JPD-240149.

DOI:10.3233/JPD-240149
PMID:39093080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11380238/
Abstract

Orthostatic hypotension (OH) is the most common manifestation of cardiovascular autonomic dysfunction in Parkinson's disease. In this viewpoint, we discuss five practical questions regarding OH in Parkinson's disease: 1) How common is the problem? 2) Why should people with Parkinson's disease and providers care about OH? 3) What are the symptoms of OH? 4) How to confirm a diagnosis of OH? And 5) How to treat OH? OH is an important non-motor symptom of Parkinson's disease for which we have available treatments to significantly mitigate morbidity and possibly positively impact the disease course.

摘要

直立性低血压(OH)是帕金森病患者心血管自主功能障碍最常见的表现。在本观点中,我们讨论了帕金森病患者 OH 的五个实际问题:1)这个问题有多常见?2)为什么帕金森病患者和提供者应该关心 OH?3)OH 的症状是什么?4)如何确诊 OH?以及 5)如何治疗 OH?OH 是帕金森病的一个重要非运动症状,我们有可用的治疗方法可以显著减轻发病率,并可能对疾病进程产生积极影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/709e/11380238/c82e50e36189/jpd-14-jpd240149-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/709e/11380238/5e91fb87f2a3/jpd-14-jpd240149-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/709e/11380238/c82e50e36189/jpd-14-jpd240149-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/709e/11380238/5e91fb87f2a3/jpd-14-jpd240149-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/709e/11380238/c82e50e36189/jpd-14-jpd240149-g002.jpg

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Hypotensive episodes at 24-h ambulatory blood pressure monitoring predict adverse outcomes in Parkinson's disease.24 小时动态血压监测中的低血压发作可预测帕金森病的不良结局。
Clin Auton Res. 2024 Apr;34(2):281-291. doi: 10.1007/s10286-024-01030-7. Epub 2024 Apr 25.
2
Orthostatic hypotension in Parkinson's disease: Sit-to-stand vs. supine-to-stand protocol and clinical correlates.帕金森病中的直立性低血压:坐-站与仰卧-站方案及临床相关性。
Parkinsonism Relat Disord. 2024 Jun;123:106980. doi: 10.1016/j.parkreldis.2024.106980. Epub 2024 Apr 22.
3
Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study.
左旋多巴对帕金森病患者体位血压变化的影响:一项随机交叉研究。
Clin Auton Res. 2024 Feb;34(1):117-124. doi: 10.1007/s10286-024-01024-5. Epub 2024 Mar 2.
4
Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association.成人高血压患者的直立性低血压:美国心脏协会的科学声明。
Hypertension. 2024 Mar;81(3):e16-e30. doi: 10.1161/HYP.0000000000000236. Epub 2024 Jan 11.
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Advice to People with Parkinson's in My Clinic: Exercise.我的诊所给帕金森患者的建议:锻炼。
J Parkinsons Dis. 2024;14(3):609-617. doi: 10.3233/JPD-230277.
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Comparison of Home and Office Blood Pressure Devices in the Clinical Setting.临床环境中家用和办公室血压测量设备的比较。
Am J Hypertens. 2024 Apr 15;37(5):342-348. doi: 10.1093/ajh/hpad120.
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Asymptomatic orthostatic hypotension in synucleinopathies: to treat or not to treat?突触核蛋白病中的无症状性直立性低血压:治疗还是不治疗?
Clin Auton Res. 2024 Feb;34(1):25-29. doi: 10.1007/s10286-023-01006-z. Epub 2023 Dec 11.
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Levodopa-induced orthostatic hypotension in parkinsonism: A red flag of autonomic failure.左旋多巴引起的帕金森病直立性低血压:自主衰竭的危险信号。
Eur J Neurol. 2024 Jan;31(1):e16061. doi: 10.1111/ene.16061. Epub 2023 Sep 19.
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