根治性前列腺切除术与放疗治疗高危前列腺癌的疗效比较。
Comparative efficacy of radical prostatectomy and radiotherapy in the treatment of high-risk prostate cancer.
出版信息
Technol Health Care. 2024;32(6):4671-4679. doi: 10.3233/THC-240910.
BACKGROUND
Both radical prostatectomy and radiation therapy are effective in controlling the condition of patients with hormone-resistant prostate cancer (HRPCa). However, there is limited research on the prognosis and quality of life of HRPCa patients after different treatment modalities.
OBJECTIVE
To explore the efficacy of radical prostatectomy (RP) and radiotherapy (RT), when treating high-risk prostate cancer (HRPCa).
METHODS
Overall 103 HRPCa patients were included and were divided into RP group and RT group according to different treatment methods. The propensity score matching method (PSM) was used to balance the baseline data of the two groups and match 34 patients in each group. The prognosis, quality of life, and basic efficacy of patients were compared.
RESULTS
After intervention, the disease-free survival rate of the RT group was higher than that of the RP group (79.41% vs. 55.88%, p= 0.038). Quality of life scores between the two treatment methods had no difference before intervention (p> 0.05), but higher in RT group than that of the RP group after intervention (p< 0.05). After treatment, there was no statistically significant difference in total effective rate of treatment between two groups (44.12% vs. 58.82%, p> 0.05), but the disease control rate was significantly higher in RT group (94.12% vs. 76.47%, p= 0.040).
CONCLUSION
Radical radiotherapy is effective in the clinical treatment of HRPCa patients, with a higher disease-free survival rate and improved quality of life after treatment, and is worth promoting.
背景
根治性前列腺切除术和放射治疗均能有效控制激素抵抗性前列腺癌（HRPCa）患者的病情。然而，对于不同治疗方式的 HRPCa 患者的预后和生活质量，研究有限。
目的
探讨根治性前列腺切除术（RP）和放疗（RT）治疗高危前列腺癌（HRPCa）的疗效。
方法
共纳入 103 例 HRPCa 患者，根据治疗方法的不同分为 RP 组和 RT 组。采用倾向评分匹配法（PSM）对两组患者的基线资料进行平衡匹配，每组匹配 34 例患者。比较两组患者的预后、生活质量及基本疗效。
结果
干预后，RT 组的无疾病生存率高于 RP 组（79.41%比 55.88%，p=0.038）。两组患者干预前的生活质量评分无差异（p>0.05），但 RT 组干预后的评分高于 RP 组（p<0.05）。治疗后，两组患者的总有效率无统计学差异（44.12%比 58.82%，p>0.05），但 RT 组的疾病控制率显著高于 RP 组（94.12%比 76.47%，p=0.040）。
结论
根治性放疗对 HRPCa 患者的临床治疗有效，无疾病生存率较高，治疗后生活质量改善，值得推广。
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