Carvajal Felipe, Luyo Gustavo, Veloso Javier, Veloso Marcelo, Alarcón Freddy, Villa Eduardo, Saavedra Erika
Instituto Nacional del Cáncer, Santiago, Chile.
Departamento de Radioterapia Oncológica, Oncosalud AUNA, Ca., Lima, Perú.
Rev Med Chil. 2023 Sep;151(9):1221-1232. doi: 10.4067/s0034-98872023000901221.
Squamous cell carcinoma of the nasopharynx is responsible for 0.7% of all malignant tumors worldwide, with the highest incidence in the population of southern China and Southeast Asia. The standard treatment for locally advanced disease consists of a combination of radiotherapy and chemotherapy in different schedules. Among them, induction chemotherapy followed by concomitant radio-chemotherapy has shown in recent years to be a standard therapeutic option with high rates of locoregional control and overall survival. This paper aims to review the current evidence related to treatment with induction chemotherapy and subsequent radio-chemotherapy in nasopharyngeal cancer, its effectiveness, and the technical aspects of its applicability.
鼻咽癌占全球所有恶性肿瘤的0.7%，在中国南方和东南亚人群中发病率最高。局部晚期疾病的标准治疗包括不同方案的放疗和化疗联合应用。其中，诱导化疗后序贯同步放化疗近年来已成为一种标准治疗选择，具有较高的局部区域控制率和总生存率。本文旨在综述目前关于鼻咽癌诱导化疗及后续放化疗治疗的相关证据、其有效性以及应用的技术方面。
