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[孤立性脾脏肿瘤作为青少年散发性伯基特淋巴瘤的一种不寻常表现]

[Solitary splenic neoplasm as an unusual presentation in an adolescent with sporadic Burkitt lymphoma].

作者信息

Diaz-Torres Carlos Julian, Abanto Hinostroza Ricardo

机构信息

Instituto Nacional de Salud del Niño San Borja, Lima, Perú.

出版信息

Andes Pediatr. 2024 Jun;95(3):297-302. doi: 10.32641/andespediatr.v95i3.4824. Epub 2024 Apr 14.

Abstract

UNLABELLED

Burkitt lymphoma is a non-Hodgkin B-cell lymphoma with a high prevalence in the pediatric population. Abdominal manifestations are well known in sporadic Burkitt lymphoma and vary from nonspecific symptoms to intestinal obstruction due to intussusception; however, mass-like splenic involvement has been scarcely described.

OBJECTIVE

To present a case of a patient with a splenic mass whose histopathological analysis revealed Burkitt lymphoma.

CLINICAL CASE

A 13-year-old female patient presented with abdominal pain, progressive weight loss, and fever. Imaging studies showed a splenic mass, intestinal thickening, and ileal intussusception. Histopathological analysis of spleen biopsy revealed Burkitt lymphoma. After the first cycle of chemotherapy (BFM95-NHL protocol), abdominal symptoms resolved; no other signs suggestive of intussusception were observed, as well as a significant reduction of the splenic mass was observed.

CONCLUSIONS

Burkitt lymphoma in pediatric patients can present as a well-defined splenic tumor, causing no splenomegaly. In addition, its management does not require surgery since it can be resolved with chemotherapy.

摘要

未标注

伯基特淋巴瘤是一种非霍奇金B细胞淋巴瘤,在儿科人群中患病率较高。散发性伯基特淋巴瘤的腹部表现众所周知,从非特异性症状到因肠套叠导致的肠梗阻不等;然而,类似肿块的脾脏受累情况鲜有描述。

目的

报告一例脾脏肿块患者,其组织病理学分析显示为伯基特淋巴瘤。

临床病例

一名13岁女性患者出现腹痛、进行性体重减轻和发热。影像学检查显示脾脏肿块、肠壁增厚和回肠套叠。脾脏活检的组织病理学分析显示为伯基特淋巴瘤。在第一个化疗周期(BFM95-NHL方案)后,腹部症状缓解;未观察到其他提示肠套叠的体征,脾脏肿块也显著缩小。

结论

儿科患者的伯基特淋巴瘤可表现为边界清晰的脾脏肿瘤,不引起脾肿大。此外,由于化疗可使其缓解,因此其治疗无需手术。

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