Ferro Matteo, De Cobelli Ottavio, Crocetto Felice, Carbone Gianluigi, Mirto Benito F, Fiorenza Mariano, Falcone Alfonso, La Civita Evelina, Fallara Giuseppe, Musi Gennaro, Rocco Bernardo, Fiori Cristian, Porpiglia Francesco, Terracciano Daniela
Division of Urology, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Department of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy.
Minerva Urol Nephrol. 2025 Feb;77(1):52-56. doi: 10.23736/S2724-6051.24.05667-2. Epub 2024 Aug 2.
Black men residing in Western countries are more likely to develop prostate cancer (PCa), have higher mortality and are younger than the general population at initial diagnosis. In addition to genetic and environmental factors, the reasons for these racial disparities can also be attributed to social determinants of health such as low health literacy of this population and poor awareness of health services. Little is known about laboratory tests for PCa in black men.
In this preliminary study. we investigated whether ethnicity affect PSA molecular forms, PHI, estradiol and testosterone levels in healthy men.
We found that healthy black men had lower PHI, [-2]proPSA/fPSA and testosterone/estradiol ratios.
Our findings even if on a small study population could have a relevant clinical impact. since PCa screening is particularly relevant in black men who are at high risk of clinically significant PCa. PSA-based screening is needed and overdiagnosis must be avoided. Our findings could be particularly impactful. Future research on larger population needs to consider whether ethnicity specific laboratory tests thresholds could help to reduce the ethnic inequalities in prostate cancer diagnosis.
居住在西方国家的黑人男性患前列腺癌（PCa）的可能性更高，死亡率更高，且初次诊断时比普通人群更年轻。除了遗传和环境因素外，这些种族差异的原因还可归因于健康的社会决定因素，如该人群的健康素养低和对医疗服务的认知不足。关于黑人男性前列腺癌的实验室检测知之甚少。
在这项初步研究中，我们调查了种族是否会影响健康男性的前列腺特异性抗原（PSA）分子形式、前列腺健康指数（PHI）、雌二醇和睾酮水平。
我们发现健康的黑人男性的PHI、[-2]前体PSA/游离PSA和睾酮/雌二醇比值较低。
我们的研究结果即使是基于小样本研究人群，也可能产生相关的临床影响。因为前列腺癌筛查对临床上有显著前列腺癌高风险的黑人男性尤为重要。需要进行基于PSA的筛查，且必须避免过度诊断。我们的研究结果可能具有特别的影响力。未来对更大人群的研究需要考虑种族特异性实验室检测阈值是否有助于减少前列腺癌诊断中的种族不平等。
